DOI: https://doi.org/10.22263/2312-4156.2018.6.55
Kuzmenka-Maskvina Y.A.
Morphologic, immunohistochemical and immunofluorescent diagnosing of typical early and advanced scleroatrophic lichen features
City Clinical Pathologoanatomic Bureau, Minsk, Republic of Belarus
Vestnik VGMU. 2018;17(6):55-63.
Abstract.
Scleroatrophic lichen (SAL) is a common chronic idiopathic skin and mucous membranes disease with a predominant involvement of the genital area. It needs dynamic observation and proper treatment. The disease manifests itself with leukodermic atrophic patches and plaques. Worldwide in general and in the Republic of Belarus in particular, patients with SAL tend to consult mainly gynecologists and urologists. At this stage usually the diagnosis of «leukoplakia» (Greek leucos white + plakos plate) is made with a further biopsy examination. Despite distinct microscopic features fully developed lesions at the early phase of their development seem not to be quite specific and persuasive thereby causing difficulties in their verification. For this very reason the disease is often not recognized histologically. The only way to the correct diagnosis is the revealing of microscopic SAL structure peculiarities with the subsequent clinicomorphologic correlation.
Key words: scleroatrophic lichen, early lesion, developed lesion, pathomorphology, dermal remodelling, immunohistochemistry, immunofluorescence.
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Information about authors:
Kuzmenka-Maskvina Y.A. – pathologist of the pathoanatomical department of general pathology No. 1, City Clinical Pathologoanatomic Bureau.
Correspondence address: Republic of Belarus, 220045, Minsk, 8/8 Semashko str., City Clinical Pathologoanatomic Bureau. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Yuliya A. Kuzmenka-Maskvina.
