DOI: https://doi.org/10.22263/2312-4156.2018.5.7
Sheibak V.M., Pauliukavets A.Y.
Biochemical heterogeneity of T-lymphocytes
Grodno State Medical University, Grodno, Republic of Belarus
Vestnik VGMU. 2018;17(6):7-17.
Abstract.
After the activation lymphocytes pass to a state of high biochemical activity, mainly reprogramming the ATP production from oxidative phosphorylation to aerobic glycolysis. The increased glucose metabolism in activated T-lymphocytes requires coordinating a variety of enzyme transcription programs to simultaneously increase glycolysis rates, glutaminolysis, lipid synthesis and cholesterol synthesis at the same time preventing lipid oxidation and sterol outflow. Regulation and switching of metabolic pathways in T-lymphocytes are associated with proliferation and differentiation processes, which are controlled by both transcriptional and post-transcriptional mechanisms, and determine both metabolism and the function / differentiation of T-lymphocytes. In addition, the metabolic status of the organism as a whole (nutrients supply, stress) can affect the metabolism of lymphocytes changing their functional activity. The study of the influence of metabolic regulation, the role of the microenvironment, the supply of substrates for the functional activity of T-lymphocytes promotes the revealing of new approaches in the therapy of the immune systempathology.
Key words: T-lymphocytes, metabolism, aerobic glycolysis, regulation of T-lymphocytes metabolism.
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Information about authors:
Sheibak V.M. – Doctor of Medical Sciences, professor of the Chair of Biologic Chemistry, Grodno State Medical University;
Pauliukavets A.Y. – Candidate of Biological Sciences, associate professor of the Chair of Microbiology, Virology and Immunology named after S.I. Gelberg, Grodno State Medical University.
Correspondence address: Republic of Belarus, 230009, Grodno, 80, Gorky str., Grodno State Medical University, Chair of Microbiology, Virology and Immunology named after S.I. Gelberg. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Anastasiya Y. Pauliukavets.
