DOI: https://doi.org/10.22263/2312-4156.2019.2.7
Katina M.A., Tikhonovskaya I.V.
Subepidermal bullous dermatoses. Part I. Dermatitis herpetiformis and linear IgA dependent bullous dermatosis
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2019;18(2):7-15.
Abstract.
This part of the article describes such autoimmune bullous skin diseases as dermatitis herpetiformis and linear IgA dependent bullous dermatosis, which have the following unifying features: the subepidermal blistering with predominantly neutrophilic infiltration on histological examination, the formation of IgA antibodies and similar clinical manifestations on the skin. In the article the attention is paid to the differences in the pathogenetic mechanisms of these pathologies development, the diagnostic features of the clinical pattern, considering the typical localization, configuration, characteristics of the primary and secondary lesions of the rash, the involvement of the mucous membranes, the development of possible complications. The article states in detail the modern approaches to the diagnosis of dermatitis herpetiformis and linear IgA dependent bullous dermatosis, including pathomorphological examination, immunofluorescence methods (DIF and IIF), serological methods of research (ELISA, immunoblotting). Taking into account the low specificity of the histological findings DIF is used for the differential diagnosis of these bullous dermatoses. The issues of serological diagnosis of these disorders aimed at the detection of specific IgA antibodies to various target antigens are highlighted as well as the approaches to therapy with possible complications monitoring.
Key words: dermatitis herpetiformis, linear IgA dependent bullous dermatosis, subepidermal blisters, DIF.
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Information about authors:
Katina M.A. – Candidate of Medical Sciences, associate professor of the Chair of Dermatovenerology, Vitebsk State Order of Peoples’ Friendship Medical University;
Tikhonovskaya I.V. – Candidate of Medical Sciences, associate professor of the Chair of Dermatovenerology, Vitebsk State Order of Peoples’ Friendship Medical University.
Correspondence address: Republic of Belarus, 210009, Vitebsk, 27 Frunze ave., Vitebsk State Order of Peoples’ Friendship Medical University, Chair of Dermatovenerology. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Mariya A. Katina.
