DOI: https://doi.org/10.22263/2312-4156.2019.3.32
Kuncevicz M.V., Ermashkevich S.N., Sachek M.G., Petukhov V.I., Tikhonova L.V.
Factors influencing the serum total testosterone levels in males with acute infectious pulmonary destructions
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2019;18(3):32-44.
Abstract.
Objectives. To study the serum total testosterone levels in males with acute infectious pulmonary destructions (AIPD) and to determine their relationship with age, duration, forms, local and systemic complications of the disease, comorbidity pathology, trophological status.
Material and methods. 64 males with AIPD and 25 healthy male subjects were examined. The study of the serum total testosterone levels was carried out with the use of the radioimmune analysis method.
Results. Testosterone deficiency was found in 77% of patients with AIPD. The lowest serum total testosterone levels, compared with lung abscesses (U=112, pMann-Whitney=0.088) and gangrenous abscesses (U=221.5; pMann-Whitney=0.045), as well as the highest frequency of androgen deficiency (89%) (pFisher=0.018) were observed in gangrene of the lung. Serum total testosterone level decreased (H=13.65; pKruskal-Wallis=0.018), the incidence of its deficiency increased (H=13.11; pKruskal-Wallis=0.022), the number of blood lymphocytes decreased (H=18.08; pKruskal-Wallis=0.0028) and the neutrophil-to-lymphocyte ratio grew (H=11.91; pKruskal-Wallis=0.036) with the development and increase in the severity of AIPD complications. There was a direct moderate correlation of serum total testosterone levels with the number of blood lymphocytes (rS=0.46; p=0.00013) and an inverse moderate correlation with the neutrophil-to-lymphocyte ratio (rS=-0.41; p=0.00077) in patients with AIPD. The correlation between the body mass index and serum total testosterone levels was lost in patients with AIPD.
Conclusions. The most significant factors affecting serum total testosterone levels and the frequency of androgen deficiency are the form and AIPD complications (F=2.55; p=0.089 and F=2.34; p=0.056 respectively). The serum total testosterone level in patients with AIPD may be considered as one of the indicators of the severity of the disease.
Key words: acute infectious pulmonary destructions, lung abscess, lung gangrene, total testosterone, androgen deficiency.
The study was performed as a part of task 3.39 «To develop and to implement set of activities for the diagnosis and treatment of metabolic disorders in acute infectious pulmonary destructions» of subprogram 3 «New technologies for coping with diseases» GSRP «Fundamental and applied sciences to medicine» (№ SR 20190175 of 14.03.2019).
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Information about authors:
Kuncevicz M.V. – postgraduate of the Chair of Hospital Surgery with the courses of Urology & Pediatric Surgery, Vitebsk State Order of Peoples’ Friendship Medical University,
ORCID: https://orcid.org/0000-0002-8122-6655
Ermashkevich S.N. – Candidate of Medical Sciences, associate professor of the Chair of Hospital Surgery with the courses of Urology & Pediatric Surgery, Vitebsk State Order of Peoples’ Friendship Medical University,
ORCID: https://orcid.org/0000-0002-0866-9070
Sachek M.G. – Doctor of Medical Sciences, professor, head of the Chair of Hospital Surgery with the courses of Urology & Pediatric Surgery, Vitebsk State Order of Peoples’ Friendship Medical University,
ORCID: https://orcid.org/0000-0001-9233-7249
Petukhov V.I. – Doctor of Medical Sciences, associate professor, head of the Chair of Surgery of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University,
ORCID: https://orcid.org/0000-0002-4042-3978
Tikhonova L.V. – Candidate of Biological Sciences, associate professor, head of the Scientific-Research Department, Vitebsk State Order of Peoples’ Friendship Medical University.
Correspondence address: Republic of Belarus, 210009, Vitebsk, 27 Frunze ave., Vitebsk State Order of Peoples’ Friendship Medical University, Chair of of Hospital Surgery with the courses of Urology & Pediatric Surgery. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Maksim V. Kuncevicz.
