DOI: https://doi.org/10.22263/2312-4156.2019.3.81
Pimanov S.I., Bondarenko V.M., Makarenko E.V.
Two-dimentional shear wave ultrasound elastography of the perirenal visceral adipose tissue in patients with metabolic syndrome
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2019;18(3):81-88.
Abstract.
Objectives. To evaluate the parameters of two-dimensional shear wave ultrasound elastography (2D-SWE) of the bottom perirenal visceral adipose tissue (BPVAT) in patients with metabolic syndrome (MS) and in healthy individuals, as well as to study the effect of the patients’ age on the elastographic characteristics of the BPVAT.
Material and methods. 49 patients, including 20 men and 29 women, were enrolled in this study. The average age of the patients was (M±σ) 42.56±6.56 years. The group of patients with MS consisted of 34 persons aged 42.19 ± 6.28 years, and the control group consisted of 15 healthy individuals whose age was 42.67 ± 7.40 years (p = 0.790). The study design was cross-sectional. The diagnosis of MS was based on the conventional international criteria. Ultrasound (US) examination was performed using a Logiq E9 (GE Healthcare, USA) ultrasound system with a convex broadband probe (C1-6D). The area of the BPVAT was determined on the right side by means of the method described earlier. 2D-SWE of the BPVAT was performed in the original modification, based on the conventional 2D-SWE method of the liver stiffness evaluation for non-invasive assessment of the fibrosis stage. The Young’s modulus (elastic modulus, stiffness) was expressed in kilopascals (kPa).
Results. The Young’s modulus of the BPVAT in patients with MS made up 5.86 ± 2.20 kPa, and in the control group it was 3.81 ± 1.27 kPa, p = 0.002. There was no statistically significant correlation with age (r = 0.248; p = 0.158), weight (r = 0.337; p = 0.051) and the BPVAT. Moderate correlation between stiffness of the BPVAT and body mass index (BMI) (r = 0.565; p <0.001), the absence of a statistically significant correlation with age (r = 0.248; p = 0.158), weight (r = 0.337; p = 0.051) and the BPVAT area (r = 0.183; p = 0.301) were found. In the control group there was no correlation with age (r = 0.430; p = 0.110), weight (r = –0.298; p = 0.281), BMI (r = 0.201; p = 0.474) and the BPVAT area (r = –0.377; p = 0.166 ).
Conclusions. The stiffness of the BPVAT in patients with MS was statistically significantly higher than that in healthy individuals. There was no association between the elastic modulus of the BPVAT and the age of both patients with MS and healthy individuals. The Young’s modulus value of the BPVAT in patients with MS correlates with that of BMI. No correlation was found between the elastic modulus and the surface area of the BPVAT to the right.
Key words: perirenal visceral adipose tissue, ultrasound investigation, elastography, shear wave, metabolic syndrome.
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Information about authors:
Pimanov S.I. – Doctor of Medical Sciences, professor, head of the Chair of Internal Medicine No.2 of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University;
Bondarenko V.M. – postgraduate of the Chair of Internal Medicine No.2 of the Faculty for Advanced Training & Retraining, senior lecturer of the Chair of Hospital Surgery with the courses of Urology & Pediatric Surgery, Vitebsk State Order of Peoples’ Friendship Medical University;
Makarenko E.V. – Doctor of Medical Sciences, professor of the Chair of Internal Medicine No.2 of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University.
Correspondence address: Republic of Belarus, 210009, Vitebsk, 27 Frunze ave., Vitebsk State Order of Peoples’ Friendship Medical University, Chair of Internal Medicine No.2 of the Faculty for Advanced Training & Retraining. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Sergey I. Pimanov.
