DOI: https://doi.org/10.22263/2312-4156.2019.4.28
Tkachenko A.S.
Inflammasomes and pyroptosis of intestinal epithelial cells: their contribution to Crohn’s disease and ulcerative colitis
Kharkiv National Medical University, Kharkiv, Ukraine
Vestnik VGMU. 2019;18(4):28-39.
Abstract.
This review article deals with the role of inflammasomes and pyroptosis of intestinal epithelial cells in the development of chronic inflammatory bowel diseases: Crohn’s disease and ulcerative colitis. Pyroptosis is a caspase-1-mediated mode of cell death associated with the cleavage of gasdermin D and release of pro-inflammatory cytokines IL-1β and IL-18. The paper covers characteristics of pyroptosis with the description of its triggers, functions, mechanisms and regulation, as well as pro-inflammatory effects of this cell death mode. Pyroptosis of intestinal epithelial cells is described in detail under normal and pathological circumstances. The pivotal role of inflammasomes and pyroptosis in the pathogenesis of chronic inflammatory bowel diseases substantiates the great importance of the development and trial of antipyroptotic drugs.
Key words: pyroptosis, inflammasomes, cell death, intestinal epithelial cells, chronic inflammatory bowel diseases, intestinal inflammation.
The author expresses his sincere gratitude to Anton Miroshnichenko for his essential help while preparing illustrations for the article.
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Information about authors:
Tkachenko A.S. – Candidate of Medical Sciences, associate professor of the Chair of Biochemistry, Kharkiv National Medical University,
ORCID: https://orcid.org/0000-0002-1029-1636
Correspondence address: Ukraine, 61022, Kharkiv, 4 Nauky ave., Kharkiv National Medical University, Chair of Biochemistry. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Anton S. Tkachenko.
