Risk factors of bronchial asthma development in children residing in Grodno region
Grodno State Medical University, Grodno, Republic of Belarus
Vestnik VGMU. 2019;18(4):67-73.
Objectives. To determine risk factors of the development of bronchial asthma in children residing in Grodno region.
Material and methods. A comparative analysis of the occurrence frequency of factors in the group of children with a verified diagnosis of bronchial asthma (n=289) and in the group of children without any chronic respiratory diseases (n=147) was made. The odds ratio (OR) and its 95% confidence internal (CI) were calculated for each factor.
Results. The occurrence frequency of the analyzed factors in the group of children with bronchial asthma exceeded those in the comparison group. For the development of bronchial asthma, the most significant factors (p<0.05) with regard to Grodno region are as follows: a burdened genealogical history concerning bronchial asthma (OR–7.44, CI: 2.92–18.97) and allergic diseases (OR–5.96, CI: 3.78–9.4), parental education at the time of childbirth (mother’s specialized secondary education OR–3.36, CI: 1.55–7.28; father’s higher education OR–1.82, CI: 1.42–2.97), bottle feeding during the first year of life (OR–6.27, CI: 2.8–14.04), frequent acute respiratory infections up to 2 years (OR–2.22, CI: 1.31–3.77), undifferentiated connective tissue dysplasia (OR–9.17, CI: 4.55–18.49), atopic dermatitis (OR–2.52, CI: 1.4–4.53), allergic reactions to drugs (OR–8.39, CI: 2.56 –27.53).
Conclusions. The results obtained can be used with the purpose of preventing and early diagnosing bronchial asthma in children on the territory of Grodno region.
Key words: children, bronchial asthma, risk factors.
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Information about authors:
Khokha R.N. – Candidate of Medical Sciences, associate professor of the Chair of Childhood Diseases No.2, Grodno State Medical University.