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DOI: https://doi.org/10.22263/2312-4156.2019.4.91

Kaban’kov A.V.1, Ivanov A.S.2, Mnatsakanov S.S.3, Rumakin V.P.4, Reznichenko A.S.5
The peculiarities of the guided bone tissue regeneration on using resorbable membranes based on polyvinyl alcohol with the addition of C60 fullerenes
1ID Studio, Saint-Petersburg, Russian Federation
2Military Medicine Academy Named after S.M. Kirov, Saint-Petersburg, Russian Federation
3Saint-Petersburg State Institute of Cinema & Television, Saint-Petersburg, Russian Federation
4Russian Order of the Red Banner of Labour Research Institute of Traumatology & Orthopedics Named after R.R. Vreden, Saint-Petersburg, Russian Federation
5Aesthetic Orthodontics Clinic «Konfidencia», Saint-Petersburg, Russian Federation

Vestnik VGMU. 2019;18(4):91-97.

Abstract.
The relevance of the study is conditioned by the increased need for full volume compensation of the bone tissue lost in case of various inflammatory diseases and injuries. A method of the guided bone tissue regeneration («bone tissue engineering») suits this purpose. Its main difference is the use of membranes that perform the barrier function separating rapidly growing connective tissue from slowly growing highly differentiated bone tissue. However, all available membranes have certain disadvantages. A promising development in this area is a resorbable membrane based on the composition of polyvinyl alcohols with the addition of nanoparticles – C60 fullerenes. For the first time in the experiment on 20 mongrel white mice, osteogenesis was compared when laying on a bone defect the resorbable membrane based on the composition of polyvinyl alcohols with the addition of C60 fullerenes and the same membrane in combination with the osteoplastic material «Osteoplast» for the guided regeneration of alveolar processes of the jaws. The morphological study of the material showed that the regenerate of the newly formed cortical layer was more mature in the group where the resorbable membrane based on the composition of polyvinyl alcohols with the addition of C60 fullerenes was used.
Key words: guided bone tissue regeneration, polyvinyl alcohol, C60 fullerenes.

References

1. Grebnev GA, Ivanov AS, Kaban'kov AV, Mnatsakanov SS, Berlin YuI. Assessment of biocompatibility of resorbed membranes based on polyvinyl alcohol with the addition of fullerenes C60. In-t Stomatologii. 2019;(1):120-2. (In Russ.)
2. Ivanov AS. Fundamentals of dental implantation: ucheb posobie. Saint Petersburg, RF: SpetsLit; 2013. 63 р. (In Russ.)
3. Ivanov AS, Kaban'kov AV, Mnatsakanov SS, Rumakin VP. Osteoplasty in surgical dentistry. Saint Petersburg, RF: SpetsLit; 2018. 79 р. (In Russ.)
4. Ivanov SYu, Larionov EV, Panin AM, Kravets VM, Anisimov SI, Volodina DN. Development of biomaterials for osteoplasty based on collagen bone tissue. In-t Stomatologii. 2005;(4):108-11. (In Russ.)
5. Kaban'kov AV, Rumakin VP, Muzykin MI, Ivanov AS. Prospects of application of resorbable tent structures on the basis of composition of polyvinyl alcohols of different degrees of saponification with addition of fulleranes c-60 and c-90. V: Aktual'nye problemy i perspektivy razvitiia stomatologii v usloviiakh Severa: sb st mezhregional nauch-prakt konf, posviashch 20-letiiu obrazovaniia stomatol otd-niia Med in-ta FGAOU VPO «Severo-Vostochnyi federal'nyi universitet imeni MK Ammosova». Yakutsk, RF; 2016. Р. 138-47. (In Russ.)
6. Prokhonchukov AA, Zhizhina NA, Leont'yev VK. Exchange of glycoproteins in the jawbone in experimental periodontal disease. V: Etiologiia i patogenez osnovnykh stomatologicheskikh zabolevanii. Moscow, RF; 1977. Р. 54-7.
7. Prokhvatilov GI, Kovalevskiy AM, Iordanishvili AK, Gordeev SA, Usikov DV. Evaluation of the results of surgical interventions on periodontal tissues with the use of membranes made of polytetrafluoroethylene by Ecoflon. V: Aktual'nye voprosy cheliustno-litsevoi khirurgii i stomatologii: sb nauch tr konf, posviashch 75-letiiu so dnia osnovaniia kaf cheliustno-litsevoi khirurgii i stomatologii. Saint Petersburg, RF; 2004. Р. 149-50. (In Russ.)
8. Usikov LV, Iordanishvili AK, Balin DV, Shengeliya EV. Morphological and clinical aspects of reparative regeneration of jaw bone tissue. Saint Petersburg, RF; 2014. 144 р. (In Russ.)
9. Masquelet AC. Muscle reconstruction in reconstructive surgery: soft tissue repair and long bone reconstruction. Langenbecks Arch Surg. 2003 Oct;388(5):344-6. doi: http://dx.doi.org/10.1007/s00423-003-0379-1
10. Bottino МС, Thomas V. Membranes for Periodontal Regeneration. Front Oral Biol. 2015;17:90-100. doi: http://dx.doi.org/10.1159/000381699
11. Dimitriou R, Mataliotakis GI, Calori GM, Giannoudis PV. The role of barrier membranes for guided bone regeneration and restoration of large bone defects: current experimental and clinical evidence. BMC Med. 2012 Jul;10:81. doi: http://dx.doi.org/10.1186/1741-7015-10-81
12. Ip WY. Polylactide membranes and sponges in the treatment of segmental defects in rabbit radii. Injury. 2002 Aug;33 Suppl 2:B66-70.
13. Mayborodin IV, Kuznetsova IV, Beregovoy EA, Shevela AI, Mayborodina VI, Manaev AA, i dr. Reaction of rat tissues to the introduction of a resorbable lactic acid-based polymer. Biul Eksperim Biologii Meditsiny. 2013;15(12):848-53. (In Russ.)
14. Ushakov SN. Polyvinyl alcohol and its derivatives. T 2. Moscow, RF; Leningrad, RF: Izd-vo Akad nauk SSSR; 1960. (In Russ.)
15. Vengerovich NG. Pathogenetic substantiation of the use of bioactive nanomaterials in the wound process: dis … kand med nauk: 14.03.03. Saint Petersburg, RF; 2011. 151 р. (In Russ.)
16. Kaban'kov AV, Popov VA, Chistyakova TA, Varlamov AV, Chezlov IG, Mnatsakanov SS; zaiavitel' i patentoobladatel' Sankt-Peterburg gos un-t kino i televideniia. Method of polyvinyl alcohol production for manufacturing of medical film material: pat. 2499012 Ros Federatsiia: MPK C08L 29/04, C08K 3/04. B82B 3/00. № 2011149449/05; zaiavl 05.12.11; opubl 20.11.13, Biul № 32. (In Russ.)
17. Orekhova LN, Orekhova LN, Kaban'kov AV, Il'ina VV, Babkin OE, Mnatsakanov SS; zaiavitel' i patentoobladatel' Sankt-Peterburg gos un-t kino i televideniia. Method for obtaining a composition based on a mixture of water-soluble polymers: pat. 2660033 Ros Federatsiia: MPK C08J 3/03, C08L 29/04, C08K 3/045, B82Y 30/00. № 2016119483; zaiavl 19.05.16; opubl 04.07.2018, Biul № 19. (In Russ.)

Information about authors:
Kaban’kov A.V. – dental surgeon, ID Studio;
Ivanov A.S. – Doctor of Medical Sciences, professor of the Chair of Maxillofacial Surgery & Operative Dentistry, Military Medicine Academy Named after S.M. Kirov;
Mnatsakanov S.S. – Doctor of Technical Sciences, professor of the Chair of Polymers & Composites Technology, Saint-Petersburg State Institute of Cinema & Television;
Rumakin V.P. – Candidate of Medical Sciences, senior research officer of the experimental and pathomorphologic department, Russian Order of the Red Banner of Labour Research Institute of Traumatology & Orthopedics Named after R.R. Vreden;
Reznichenko A.S. – dentist, Aesthetic Orthodontics Clinic «Konfidencia».

Correspondence address: Russian Federation, 197000, Saint-Petersburg, 16 Pirogov per., ID Studio. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Andrey V. Kaban’kov.

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