DOI: https://doi.org/10.22263/2312-4156.2019.5.12
Belyaeva L.E., Pauliukevich A.N.
The early programming of human diseases and the application of nutraceuticals for their prevention: focus on fish oil. Literature review. Part 2
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2019;18(5):12-25.
Abstract.
In the second part of this review the results of numerous experimental, clinical and epidemiological studies devoted to the influence of ω-3 polyunsaturated fatty acids (ω-3 PUFA)-containing nutraceuticals on the characteristic and peculiarities of intrauterine development and also the effects observed in different periods of postnatal development in organisms born by mothers whose pregnancy proceeded in adverse conditions have been analyzed and discussed. The main mechanisms of prenatal stress outcomes minimization with ω-3 PUFA by their influence on the inflammatory process, oxidative stress, organization of structural cell components as well as participation in epigenetic regulation of gene expression and various disorders programming as a whole are discussed.
Key words: omega-3 polyunsaturated fatty acids, prenatal stress, oxidative stress, systemic low grade inflammation, lipid «rafts», caveolae, epigenetic mechanisms.
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Information about authors:
Belyaeva L.E. – Candidate of Medical Sciences, associate professor, head of the Chair of Pathologic Physiology, Vitebsk State Order of Peoples’ Friendship Medical University;
Pauliukevich A.N. – Master of Medical Sciences, lecturer of the Chair of Pathologic Physiology, Vitebsk State Order of Peoples’ Friendship Medical University.
Correspondence address: Republic of Belarus, 210009, Vitebsk, 27 Frunze ave., Vitebsk State Order of Peoples’ Friendship Medical University, Chair of Pathologic Physiology. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Lyudmila E. Belyaeva.
