DOI: https://doi.org/10.22263/2312-4156.2019.5.26
Minina E.S., Novikov P.D., Senkovich S.A.
Eosinophil extracellular traps: their role in health and disease
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2019;18(5):26-34.
Abstract.
The review presents the current data about a new mechanism of antimicrobial action of eosinophilic granulocytes – the formation of eosinophil extracellular traps (EETs). The extraction of extracellular DNA traps was also detected in neutrophils, mast cells, monocytes, tissue macrophages and lymphocytes. The formation of extracellular traps, apart from humans, was observed in fish, bull, horse, cat, mouse and hen. The death of eosinophils with the release of extracellular DNA traps is called «EETosis». The main structural components of eosinophil extracellular traps, factors stimulating their appearance and mechanisms of the antimicrobial action of eosinophil extracellular DNA traps are described in the article. The main infectious, inflammatory and allergic diseases , in which EETs formation was observed, are presented in this review. The study of new immunological mechanisms of the human body defense, such as the formation of extracellular traps by various immune system cells, appears to be of great interest not only for scientists, but also for practicing physicians.
Key words: eosinophils, eosinophil extracellular traps, EETosis, DNA.
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Information about authors:
Minina E.S. – Candidate of Medical Sciences, lecturer of the Chair of Pediatrics, Vitebsk State Order of Peoples’ Friendship Medical University;
Novikov P.D. – Doctor of Medical Sciences, professor of the Chair of Clinical Immunology and Allergology with the course of the Faculty for Advanced Training and Retraining, Vitebsk State Order of Peoples’ Friendship Medical University;
Senkovich S.A. – Candidate of Medical Sciences, associate professor of the Chair of Clinical Microbiology, Vitebsk State Order of Peoples’ Friendship Medical University.
Correspondence address: Republic of Belarus, 210009, Vitebsk, 27 Frunze ave., Vitebsk State Order of Peoples’ Friendship Medical University, Chair of Pediatrics. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Elena S. Minina.
