Zhuravleva L.N., Novikova V.I.
The assessment of the concentration of surfactant protein D in the blood serum and tracheobronchial secretion in respiratory distress syndrome and congenital pneumonia in premature newborns
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2019;18(6):43-49.
One of the major causes of morbidity in newborns is the respiratory tract pathology. Among the premature infants, the leading cause is given to pneumonia and respiratory distress syndrome (RDS).
Objectives. To assess the concentration of surfactant protein D (SP-D) in the secretion of the tracheobronchial tree and in the blood serum of children with congenital pneumonia and respiratory distress syndrome.
Material and methods. We observed 45 newborns with respiratory disorders (27 children with congenital pneumonia and 18 children with respiratory distress syndrome), the comparison group consisted of 20 «almost healthy» newborns without any tracheobronchial pathology.
Results. The concentration of SP-D in the group of «almost healthy» premature newborns made up 1.97 ng / ml (25-75 IQR 1.3-2.14 ng / ml). The concentration of SP-D in the serum of patients with congenital pneumonia was 35.78 ng / ml (25-75 IQR 25.57-41.63 ng / ml) during 1-2 days, and thereafter on the 10th-14th day it was also significantly higher (p<0.001) in comparison with premature infants without respiratory diseases and children with RDS (p<0.001). We found a positive correlation between the severity of pneumonia and the increase in serum SP-D levels on the 1st - the 2nd day of life in patients with an unfavorable outcome of pneumonia (r=0.62, p<0.001). We also determined that the blood serum SP-D level of 21.8 ng / ml in preterm infants may be used as a diagnostic criterion for the prognostically unfavorable course of congenital pneumonia.
Key words: newborns, respiratory distress syndrome, pneumonia, immune status, surfactant protein D, premature infants.
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Information about authors:
Zhuravleva L.N. – Candidate of Medical Sciences, associate professor of the Chair of Pediatrics, Vitebsk State Order of Peoples’ Friendship Medical University;
Novikova V.I. – Doctor of Medical Sciences, professor, head of the Chair of Pediatrics of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University.