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Javadova G.Ch.1, Ioshin I.E.2, Musayev P.I.1, Guliyeva S.T.1
The role of prostaglandin analogs in the development of macular edema on their perioperative application in patients suffering from cataract with concurrent primary open-angle glaucoma
1Azerbaijan Medical University, Baku, Azerbaijan
2Federal State Budgetary Institution «Clinical Hospital», Office of the President of the Russian Federation, Moscow, Russian Federation

Vestnik VGMU. 2019;18(6):8-15.

Prostaglandin analogs (PGAs) are the first-line drugs used for intraocular pressure (IOP) reduction and have been widely applied in the perioperative management of the patients suffering from cataract with concurrent primary open-angle glaucoma (POAG). These drugs possess a significant hypotensive effect, are easy in use, cause few complications and work well in combination with other medicinal agents. However, being inflammation mediators, they theoretically can result in the development of postoperative cystoid macular edema (ME).
A review of the literature data shows that the evaluation of the participation of PGAs in the development of cystoid macular edema in the postoperative period after phacoemulsification by experts is not straightforward.  Some specialists assert that PGAs increase the permeability of the blood-aqueous barrier, and thus can contribute to the development of cystoid ME, especially in the early postoperative period. Other experts, on the contrary, completely exclude the likelihood of any connection between the development of cystoid postoperative ME and PGAs application, explaining this by the fact that a locally used drug hardly passes into the posterior part of the eyeball and therefore cannot produce a clinically significant effect on the retina. Although much research has been performed, the answer to this question remains open up to this date.
Key words: prostaglandin analogs, cataract phacoemulsification, cystoid macular edema, primary open-angle glaucoma.


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Information about authors:
Javadova G.Ch. – postgraduate of the Chair of Ophthalmology, Azerbaijan Medical University, Azerbaijan;
Ioshin I.E. – Doctor of Medical Sciences, professor, head of the ophthalmologic department, Federal State Budgetary Institution «Clinical Hospital», Office of the President of the Russian Federation, Russian Federation;
Musayev P.I. – Doctor of Medical Sciences, professor, head of the Chair of Ophthalmology, Azerbaijan Medical University, Azerbaijan;
Guliyeva S.T. – Candidate of Biological Sciences, associate professor of the Chair of Pharmacology, Azerbaijan Medical University, Azerbaijan.

Correspondence address: Azerbaijan, AZ1022, Baku, 23 Bakikhanov str., Azerbaijan Medical University, Chair of Ophthalmology. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Gyunesh Ch. Javadova.

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