DOI: https://doi.org/10.22263/2312-4156.2020.2.7
Liasnikau K.A., Shliakhtunou Y.A.
Clinical significance of molecular-genetic markers in the diagnosis and personalization of lung cancer therapy
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2020;19(2):7-18.
Abstract.
The article presents a review of the modern literature concerning the molecular-genetic diagnosis of lung cancer. The characteristics of mutations in the family oncogenes, such as epidermal growth factor receptor EGFR, survivin (BIRC5), KRAS (EML4-ALK), Herceptin 2 (HER2), P53, v-raf murine sarcoma (BRAF), etc. are presented. Their clinical significance, prognostic and predictive value in lung cancer have been established. With the help of modern diagnostic methods, it is possible to determine the expression of the indicated genes both directly in the tumor tissue obtained by biopsy and in circulating tumor cells of the peripheral blood. The molecular approach to the diagnosis of lung cancer by analyzing biomarkers obtained with the help of a non-invasive way is promising and relevant in order to individualize the treatment (surgical, neo- and adjuvant drug) tactics for patients suffering from lung cancer.
Key words: cancer, mutation, tumor marker, genetic diagnosis.
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Information about authors:
Liasnikau K.A. – postgraduate of the Chair of Oncology with the courses of Radiodiagnosis & Radiotherapy and the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University,
ORCID: https://orcid.org/0000-0001-5649-4044
Shliakhtunou Y.A. – Candidate of Medical Sciences, associate professor of the Chair of Oncology with the courses of Radiodiagnosis & Radiotherapy and the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University;
ORCID: https://orcid.org/0000-0002-5906-5373
Correspondence address: Republic of Belarus, 210009, Vitebsk, 27 Frunze ave, Vitebsk State Order of Peoples’ Friendship Medical University, Chair of Oncology with the courses of Radiodiagnosis & Radiotherapy and the course of the Faculty for Advanced Training & Retraining. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. –Kanstantsin A. Liasnikau.
