DOI: https://doi.org/10.22263/2312-4156.2020.3.7
Makarevich O.O.
Intravitreal injections in retinoblastoma treatment
Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Republic of Belarus
Vestnik VGMU. 2020;19(3):7-13.
Abstract.
Retinoblastoma is the most common primary intraocular malignancy in infancy and childhood. There are many modalities for the management of retinoblastoma including polychemotherapy and focal consolidation therapeutic methods of tumoral process control (cryodestruction, transpupillary thermotherapy, transpupillary thermochemotherapy, laser ablation and others) that allow to avoid enucleation or external beam radiotherapy. Good results are usually achieved by providing systemic or intra-arterial chemotherapy combined with focal laser therapy, but the presence of vitreous seeds is an obstacle and it affects the final prognosis and eye salvage. Intravitreal injection of cytotoxic drugs in retinoblastoma is a method of treating vitreous seeds that cannot be treated with any other methods. Vitreous seeds without intravitreal injections application subsequently lead to the progression of the disease and to the eyeball enucleation. Several therapeutic agents were used for administering intravitreal injections such as thiotepa, melphalan, carboplatin and methotrexate, etc. Kaneko and Suzuki in their researches have found out that melphalan was the most effective drug among 12 drugs tested in vitro, and afterwards it has also been found that this drug is not toxic to the retina.
Key words: retinoblastoma, intravitreal injections, vitreous seeds, cytotoxic drugs.
I express profound gratitude to my scientific supervisor Konoplya Natalya Evgenyevna for her critical analysis and revising this article.
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Information about authors:
Makarevich O.O. – postgraduate of the Belarusian Research Center for Pediatric Oncology, Hematology and Immunology.
Correspondence address: Republic of Belarus, 223053, Minsk district, village of Borovlyany, 43 Frunzenskaya str., Belarusian Research Center for Pediatric Oncology, Hematology and Immunology. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Oksana O. Makarevich.
