DOI: https://doi.org/10.22263/2312-4156.2020.5.48
Keda L.N.1, Gutikova L.V.2
The amino acids and biogenic amines content in the blood plasma of women with artificial termination of pregnancy due to medical indications on the part of the fetus
1Ministry of Health of the Republic of Belarus, Minsk, Republic of Belarus
2Grodno State Medical University, Grodno, Republic of Belarus
Vestnik VGMU. 2020;19(5):48-58.
Abstract.
Artificial termination of pregnancy at late stages harms the physical and mental health of a woman. Taking into account that amino acids and biogenic amines are universal regulators of biochemical processes in the body, changes of their concentrations can be used as the indicators of pathological processes formation after termination.
Objectives. To examine the levels of free amino acids and their derivatives in the blood plasma of women with artificial termination of pregnancy due to medical indications on the part of the fetus, to find special features of the changes of individual free amino acids and their total concentration before and after termination of pregnancy.
Material and methods. 104 women with prenatally diagnosed congenital malformations and chromosomal abnormalities of the fetus (group I), and 25 women with physiological course of pregnancy (group II) were examined. The levels of free amino acids and their nitrogen-containing derivatives in blood plasma were determined by high-performance liquid chromatography method.
Results. Among the pregnant women in group I an increase by 15% (p<0.001) in the total amount of amino acids in blood plasma, by 12.3% (p=0.003) in the total content of essential amino acids, as well as by 13.6% (p<0.001) in the level of non-essential amino acids was noticed as compared with the control group.
When comparing the levels of amino acids among women in group I before and after termination of pregnancy on the first day, an increase in the total content of amino acids by 18% (p<0.001), essential amino acids by 21.5% (p<0.001), non-essential amino acids by 17.8% (p<0.001) was determined as compared with the values before termination of pregnancy.
Conclusions. The examination of special features of amino acids metabolism shows that women with pathological conditions of the fetus that require termination of pregnancy at late stages have significant changes in amino acid metabolism, which continue after the artificial termination of pregnancy and can lead to the disturbance of general hemostasis.
Key words: artificial termination of pregnancy, fetus, congenital malformations, chromosomal abnormalities, free amino acids.
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Information about authors:
Keda L.N. – main specialist of the Department of Medical Care for Mothers & Children of the Main Directorate of the Organization of Medical Care, Ministry of Health of the Republic of Belarus;
Gutikova L.V. – Doctor of Medical Sciences, professor, head of the Chair of Obstetrics & Gynecology, Grodno State Medical University.
Correspondence address: Republic of Belarus, 220048, Minsk, 39 Myasnikova str., Ministry of Health of the Republic of Belarus, Department of Medical Care for Mothers & Children. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Ludmila N. Keda.
