DOI: https://doi.org/10.22263/2312-4156.2020.5.66
Shchastniy A.T.1, Lud N.G.1, Sobol V.N.1, Kozhar V.L.1, Ermolenko N.V.2
The analysis of the patients’ survival rate in the comprehensive treatment for cancer of the head of the pancreas
1Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
2Vitebsk Regional Clinical Oncological Center, Vitebsk, Republic of Belarus
Vestnik VGMU. 2020;19(5):66-71.
Abstract.
The aim of this study is to evaluate recent and remote results of the comprehensive treatment of patients with cancer of the head of the pancreas.
The analysis of the comprehensive treatment results of 82 patients suffering from cancer of the head of the pancreas and being operated on in 2011-2015 has been made. The study has found that postoperative mortality after radical operations made up 7.32%, the one-year survival rate was 45.12%, the three-year survival rate amounted to 24.39%, the five-year survival rate was 10.98%, the median life-span of all the deceased patients made up 19.9 months. On the day of the completion of the study 11 (13.4%) patients are followed-up whose life-span after operation is from 47.2 months to 88.5 months, 7 out of them have no signs of the progression of the tumor process. While evaluating the treatment efficacy it has been established that adjuvant chemotherapy doesn’t put off the onset of the disease progression, but prolongs the mean length of patients’ life up to 29.9 months. The combination of systemic medicamentous therapy and radiotherapy in the postoperative period produces a more pronounced curative effect and doubles the mean life-span compared to patients who didn’t undergo chemo-radiotherapy at all.
Key words: cancer of the head of the pancreas, treatment results.
References
1. Shmak AI, Revtovich MIu, Iakubovich IA. Results of complex treatment of resectable pancreatic head cancer. Onkol Zhurn. 2014;8(3):60-5. (In Russ.)
2. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016 Jan-Feb;66(1):7-30. doi: http://dx.doi.org/10.3322/caac.21332
3. Haller DG. Future directions in the treatment of pancreatic cancer. Semin Oncol. 2002 Dec;29(6 Suppl 20):31-9. doi: http://dx.doi.org/10.1053/sonc.2002.37381
4. van Heerden JA, ReMine WH, Weiland LH, McIlrath DC, Ilstrup DM. Total pancreatectomy for ductal adenocarcinoma of the pancreas. Mayo Clinic experience. Amer. J. Surg. 1981 Sep;142(3):308-11. doi: http://dx.doi.org/10.1016/0002-9610(81)90336-6
5. Statistics of morbidity and mortality from malignant neoplasms in 2000. V: Davydov MI, Aksel EM. Zlokachestvennye novoobrazovaniia v Rossii i stranakh SNG v 2000 g. Moscow, RF: RONTs im HH Blokhina RAMN; 2002. Р. 85-106. (In Russ.)
6. Sukonko OG, Krasnyi SA, red. Algorithms for the diagnosis and treatment of patients with malignant neoplasms. Minsk, RB; 2012. Vyp 2. 512 р. (In Russ.)
7. Okeanov AE, Moiseev PI, Levin LF, Evmenenko AA, Ipatii TB; Sukonko OG, red. Cancer in Belarus: figures and facts. Analysis of data from the Belarusian Cancer Register for 2009-2018. Minsk, RB: Nats b-ka Belarusi; 2019. 420 р. (In Russ.)
8. Patiutko IuI, Sagaidak IV. Diagnosis and treatment of pancreatic cancer. Vestn RONTs NN Blokhina RAMN. 2006;17(2 pril 1):36-7. (In Russ.)
9. Putov NV, Artemeva NN, Kokhanenko NIu. Pancreas cancer. Saint Petersburg, RF: Piter; 2005. 416 р. (In Russ.)
10. Shchastnyi AT, Sobol VN, Lud NG, Kozhar VL. Survival of patients after surgical treatment of pancreatic head cancer. V: Shchastnyi AT, red. Dostizheniia fundamental'noi, klinicheskoi meditsiny i farmatsii [Elektronnyi resurs]: materialy 73-i nauch ses VGMU (29-30 ianv 2018 g.) : v 2 ch. Vitebsk, RB: VGMU; 2018. Ch 1. R. 70-3. 1 elektron opt disk (CD-ROM). Zagl s etiketki diska. (In Russ.)
11. Shchastnyi AT, Sobol VN, Lud NG, Kozhar VL. A retrospective analysis of the results of complex treatment for cancer of the head of the pancreas. V: Shchastnyi AT, red. Dostizheniia fundamental'noi, klinicheskoi meditsiny i farmatsii [Elektronnyi resurs]: materialy 74-i nauch ses VGMU (23-24 ianv 2019 g.). Vitebsk, RB: VGMU; 2019. R. 56-8. 1 elektron opt disk (CD-ROM). Zagl s etiketki diska. (In Russ.)
12. van der Gaag NA, Rauws EAJ, van Eijck CHJ, Bruno MJ, van der Harst E, Kubben FJGM, et al. Preoperative biliary drainage for cancer of the head of the pancreas. N Engl J Med. 2010 Jan;362(2):129-37. doi: http://dx.doi.org/10.1056/NEJMoa0903230
13. Klimov AE, Gaboian AS, Lebedev NV, Barkhudarov AA, Persov MIu. Long-term results of surgical treatment of patients with cancer of the organs of the biliopancreatoduodenal region. 2014;(5):37-41. (In Russ.)
14. Mikhailov IV, Bondarenko VM, Kudriashov VA, Prigozhaia TI, Podgornyi NN, Shimanovskii GM, i dr. Results of surgical treatment of pancreatic cancer. Problemy Zdorov'ia Ekologii. 2014;(1):46-51. (In Russ.)
15. Seppänen H, Juuti A, Mustonen H, Haapamäki C, Nordling S, Carpelan-Holmström M, et al. The Results of Pancreatic Resections and Long-Term Survival for Pancreatic Ductal Adenocarcinoma: A Single-Institution Experience. Scand J Surg. 2017 Mar;106(1):54-61. doi: http://dx.doi.org/10.1177/1457496916645963
16. Fang Y, Gurusamy KS, Wang Q, Davidson BR, Lin H, Xie X, et al. Pre-operative biliary drainage for obstructive jaundice. Cochrane Database Syst Rev. 2012 Sep;9(9):CD005444. doi: http://dx.doi.org/10.1002/14651858.CD005444.pub3
17. Janes RH, Niederhuber JE, Chmiel JS, Winchester DP, Ocwieja KC, Karnell JH, et al. National patterns of care for pancreatic cancer. Results of a survey by the Commission on Cancer. Ann Surg. 1996 Mar;223(3):261-72. doi: http://dx.doi.org/10.1097/00000658-199603000-00006
18. Стенина МБ. Системная противоопухолевая терапия при раке органов билиопанкреатодуоденальной зоны. Практ Онкология Stenina MB. Systemic antitumor therapy for cancer of the organs of the biliopancreatoduodenal zone. Prakt Onkologiia. 2004;5(2):154-62.
19. Kabanov MIu, Solovev IA, Sementcov KV, Ambartcumian SV, Iakovleva DM. Pancreatic cancer - modern views on the problem. Annaly Khirurg Gepatologii. 2012;17(4):106-10. (In Russ.)
Information about authors:
Shchastniy A.T. – Doctor of Medical Sciences, professor of the Chair of Surgery of the Faculty for Advanced Training & Retraining, rector, Vitebsk State Order of Peoples’ Friendship Medical University;
Lud N.G. – Doctor of Medical Sciences, professor, head of the Chair of Oncology with the courses of Radiodiagnosis & Radiotherapy and the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University;
Sobol V.N. – Candidate of Medical Sciences, associate professor of the Chair of Oncology with the courses of Radiodiagnosis & Radiotherapy and the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University;
Kozhar V.L. – Candidate of Medical Sciences, associate professor of the Chair of Oncology with the courses of Radiodiagnosis & Radiotherapy and the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University;
Ermolenko N.V. – oncologist, head of the organizational and methodological department, Vitebsk Regional Clinical Oncological Center.
Correspondence address: Republic of Belarus, 210009, Vitebsk, 27 Frunze ave., Vitebsk State Order of Peoples’ Friendship Medical University, Chair of Oncology with the courses of Radiodiagnosis & Radiotherapy and the course of the Faculty for Advanced Training & Retraining. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Nikolay G. Lud.
