DOI: https://doi.org/10.22263/2312-4156.2020.6.86
Navumau A.D.
The content of sex steroids and their reception in experimental animals under the conditions of chronic radiation impact
Vitebsk State Awarded the «Badge of Honour» Order Veterinary Medicine Academy, Vitebsk, Republic of Belarus
Vestnik VGMU. 2020;19(6):86-91.
Abstract.
The problem of the possible consequences of long-term low doses exposure to ionizing radiation still remains little-studied. The complexity associated with assessment and prognostication in these studies are linked with the activity of cell reparation systems that help the organisms to adapt to the changing internal and external environmental conditions.
Objectives. To show the current state of the problem of small doses impact of ionizing radiation, the main focus being on the content in the blood and reception of estradiol and progesterone in a target organ (rat’s uterus) exposed to external radiation.
Material and methods. The experiments were conducted on mongrel laboratory female rats. Standard diagnostic kits were used to measure the blood levels of estradiol and progesterone. The reception of the steroids was studied with the help of a radioligand method.
Results. The early and remote effects of long-time ionizing radiation on the content of estradiol and progesterone in the blood and their reception in target organs have been studied. It has been established that in the conditions of an experiment external gamma radiation didn’t cause any reliable change in sex steroids of the blood. A change in the quantity of estradiol and progesterone cytosolic receptors has been found in the uterus of irradiated female rats.
Conclusions. Chronic gamma radiation exerts a destabilizing effect on the system of steroid regulation, which can lead to a disturbance of physiological functions in the body.
Key words: estradiol, progesterone, blood, steroid hormone content, hormone receptors, γ-irradiation.
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Information about authors:
Navumau A.D. – Doctor of Biological Sciences, professor of the Chair of Radiology & Biophysics, Vitebsk State Awarded the «Badge of Honour» Order Veterinary Medicine Academy.
Correspondence address: Republic of Belarus, 210036, Vitebsk, 14 Nezavisimosty ave. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Aliaksandr D. Navumau.
