DOI: https://doi.org/10.22263/2312-4156.2021.1.24
Tilitskaja E.M., Semenov G.V., Dashkevich E.V.
HLA-associated antiplatelet antibodies. Literature review
Republican Scientific and Practical Center for Transfusiology and Medical Biotechnologies, Minsk, Republic of Belarus
Vestnik VGMU. 2021;20(1):24-30.
Abstract.
The article presents a literature review of publications on the topic: HLA-associated antiplatelet antibodies. The role of HLA-antiplatelet antibodies in the development of refractoriness during platelet concentrate transfusions is described. Despite the improvement in the methods of preparation, storage of blood and its components, careful adherence to the rules of transfusion, unfortunately, post-transfusion hemolytic and non-hemolytic reactions and complications remain a frequent occurrence. With multiple transfusions of platelet mass, some patients may become refractory to repeated transfusions of platelets, associated with the development of an alloimmunization state in them. The success of replacement therapy depends on the number of platelets transfused and their functional usefulness. The effectiveness of platelets transfusion is assessed by their increase immediately after, one hour and one day after the transfusion. Their growth in a day can be affected by concomitant hematological complications. To minimize the risk of the development of refractoriness to donor platelets and the occurrence of transfusion reactions and post-transfusion complications, it is necessary to select «donor-recipient» pairs, taking into account the assessment for their compatibility by antigens of the HLA system at loci A and B.
Key words: HLA antigens, HLA antibodies, refractoriness, platelet transfusions.
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Information about authors:
Tilitskaya E.M. – postgraduate student, biologist of the II category of the Laboratory of Experimental Production, Republican Scientific and Practical Center for Transfusiology and Medical Biotechnologies;
Semenov G.V. – Candidate of Medical Sciences, doctor of laboratory diagnosis of the Laboratory of HLA-Typing of Organs and Tissues, Republican Scientific and Practical Center for Transfusiology and Medical Biotechnologies;
Dashkevich E.V. – Candidate of Medical Sciences, head of the Laboratory of Transfusiology, Republican Scientific and Practical Center for Transfusiology and Medical Biotechnologies.
Correspondence address: Republic of Belarus, 220053, Minsk, 160 Dolginovsky tract, Republican Scientific and Practical Center for Transfusiology and Medical Biotechnologies. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. –Ekaterina M. Tilitskaya.
