DOI: https://doi.org/10.22263/2312-4156.2021.1.7
Vykhrystsenka L.R., Schastlivenko A.I., Bondarаva L.I., Sidarenka A.V., Muzyka O.G.
Kidney damage in Covid-19 infection
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2021;20(1):7-23.
Abstract.
When writing the review, the published data on the pathogenesis, clinical manifestations, treatment and rehabilitation of kidney damage caused by SARS-CoV-2 infection (Severe acute respiratory syndrome coronavirus 2) were summarized and compared. Kidney damage can occur as a result of the involvement of the SARS-CoV-2 virus in the renin-angiotensin-aldosterone system (RAAS), on the development of a cytokine storm, ischemia, chain pulmonary-renal pathogenetic reaction, hypercoagulation, rhabdomyolysis. Kidney damage is observed in severe COVID-19 in 25-50% of cases and manifests itself by proteinuria and hematuria, tubular dysfunction, and acute kidney injury (AKI) develops in about 15% of cases. Patients with AKI and chronic kidney disease (CKD) are a high mortality group when they develop COVID-19 infection. In case of kidney damage caused by SARS-CoV-2, the general principles of treatment are used – symptomatic and renal replacement therapy, control over the administration of nephrotoxic drugs is exercised. It is required to determine the tactics of dispensary observation of patients with COVID-19 kidney disease (chronic kidney disease, acute kidney damage or renal replacement therapy).
Key words: coronavirus infection, COVID-19, acute kidney damage, chronic kidney disease, case management.
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Information about authors:
Vykhrystsenka L.R. – Doctor of Medical Sciences, professor, head of the Chair of General Medical Practice, Vitebsk State Order of Peoples’ Friendship Medical University;
Schastlivenko A.I. – Candidate of Medical Sciences, associate professor of the Chair of General Medical Practice, Vitebsk State Order of Peoples’ Friendship Medical University;
Bondarava L.I. – senior lecturer of the Chair of General Medical Practice, Vitebsk State Order of Peoples’ Friendship Medical University;
Sidarenka A.V. – senior lecturer of the Chair of General Medical Practice, Vitebsk State Order of Peoples’ Friendship Medical University;
Muzyka O.G. – senior lecturer of the Chair of General Medical Practice, Vitebsk State Order of Peoples’ Friendship Medical University.
Correspondence address: Republic of Belarus, 210009, Vitebsk, 27 Frunze ave., Vitebsk State Order of Peoples’ Friendship Medical University, Chair of General Medical Practice. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Liudmila R. Vykhrystsenka.
