DOI: https://doi.org/10.22263/2312-4156.2021.5.42
Starovoitov A.G.1, Lipnitski A.L.2,3, Marochkov А.V.2,3
Platelet aggregation in donors of platelet mass and fresh frozen plasma
1Mogilev Regional Blood Transfusion Station, Mogilev, Republic of Belarus
2Mogilev Regional Clinical Hospital, Mogilev, Republic of Belarus
3Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2021;20(5):42-48.
Abstract.
Currently, the most common method in clinical practice, that enables the determination of the functional state of platelets, is the method of platelet aggregation.
Objectives. To study the aggregation of platelets in donors of platelet mass and fresh frozen plasma.
Material and methods. The study included 31 donors of fresh frozen plasma and platelet mass. The study of platelet aggregation was carried out by the turbidimetric measurement technique on the AP2110 analyzer (ZAO «SOLAR», Minsk, Republic of Belarus) with an inductor: ADP (concentrations of 0.3 μg/ml, 0.6 μg/ml, 1.25 μg/ml and 2.5 μg/ml were used), epinephrine (concentrations of 2.5 μM and 5.0 μM were used), collagen (concentration of 2 mg/ml).
Results. 33 analysis of platelet aggregation were performed in donors prior to collection of platelet mass and fresh frozen plasma. Only in 10 cases (30.3%) donors had normal platelet aggregation, hypoaggregation was detected in 15 cases (45.5%) and hyperaggregation – in 8 studies (24.2%). Impaired platelet aggregation was detected in all donors who had COVID-19 infection in their anamnesis (in 5 – hypoaggregation, in 4 – hyperaggregation). In donors who didn’t have this infection in their anamnesis, the incidence of platelet aggregation disorders was statistically significantly lower – 63.6% (in 10 – hypoaggregation, in 4 – hyperaggregation), p=0.04. The presence of COVID-19 infection in the donor’s anamnesis is an independent predictor of impaired platelet aggregation (Chi-square=7.24, p=0.007).
Conclusions. The study of platelet aggregation must be mandatory before collecting platelet mass in all donors.
Key words: platelet aggregation, platelets, platelet mass, thromboconcentrate, fresh frozen plasma, new coronavirus infection, COVID-19.
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Information about authors:
Starovoitov A.G. – valeologist, Mogilev Regional Blood Transfusion Station,
ORCID: https://orcid.org/0000-0003-3884-8712
Lipnitski A.L. – Candidate of Medical Sciences, anesthesiologist-resuscitator, head of the department for taking organs and tissues for transplantation, Mogilev Regional Clinical Hospital; lecturer of the affiliated branch of the Chairs of Anesthesiology and Resuscitation with the course of the Faculty for Advanced Training & Retraining and Hospital Surgery of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University,
ORCID: https://orcid.org/0000-0002-2556-4801
Marochkov A.V. – Doctor of Medical Sciences, professor, anesthesiologist-resuscitator of the anesthesiology and resuscitation department, Mogilev Regional Clinical Hospital; professor of the affiliated branch of the Chairs of Anesthesiology and Resuscitation with the course of the Faculty for Advanced Training & Retraining and Hospital Surgery of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University,
ORCID: https://orcid.org/0000-0001-5092-8315
Correspondence address: Republic of Belarus, 212016, Mogilev, 12 Belynitsky-Birula str., Mogilev Regional Clinical Hospital, the department for taking organs and tissues for transplantation. E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Artur L. Lipnitski.
