DOI: https://doi.org/10.22263/2312-4156.2022.5.89
A.T. Shchastniy, A.V. Shulmin, E.V. Mikhnevich
The detection of predictors probabilistic characteristics of acute renal graft rejection on the part of a recipient
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2022;21(5):89-95.
Abstract.
Acute renal graft rejection (ARGR) may be the cause of its dysfunction and loss in the postoperative period.
Objectives. To identify possible predictors of ARGR based on the analysis of the alleged risk factors on the part of a recipient.
Material and methods. A retrospective study of medical cards of 248 patients who underwent cadaveric kidney allotransplantation (CKA) was carried out. The influence of the following factors on the probability of developing ARGR was assessed: weight, age, blood group, Rh factor, gender of a recipient, duration of renal replacement therapy (RRT). Data processing was carried out by CRT analysis for the “decision tree” method (SPSS Statistics 22 program), and also using Pearson’s chi-square test (Statistica software package).
Results. The study has revealed that being on RRT for more than 9.5 months statistically significantly increases the likelihood of developing ARGR in the postoperative period, especially in the group of patients with IV (AB) blood type.
Conclusions. Factors such as the duration of RRT for more than 9.5 months and the IV(AB) blood group a type of a recipient, both individually and in combination, can be considered as predictors of ARGR development. Therefore, measures to reduce the incidence of ARGR should be aimed at reducing the duration of RRT, as well as restrictions of recipients with IV(AB) blood group type on being under RRT for more than 9.5 months.
Keywords: acute renal graft rejection, recipient blood group type, duration of renal replacement therapy, kidney transplantation, reduction in the duration of renal replacement therapy, promotion on the waiting list.
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Information about authors:
A.T. Shchastniy – Doctor of Medical Sciences, professor, head of the Chair of Hospital Surgery with the course of the Faculty for Advanced Training & Retraining, rector of Vitebsk State Order of Peoples’ Friendship Medical University, https://orcid.org/0000-0003-2796-4240
A.V. Shulmin – Doctor of Medical Sciences, professor, head of the Chair of Management and Marketing of Pharmacy, Vitebsk State Order of Peoples’ Friendship Medical University, https://orcid.org/0000-0002-5087-8255
E.V. Mikhnevich – senior lecturer of the Chair of Public Health & Health Service with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University, https://orcid.org/0000-0001-8591-7376
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