DOI: https://doi.org/10.22263/2312-4156.2022.6.29
Y.V. Savich, Ya.I. Isaikina, M.A. Novikova
Characteristic of exosomes and their potential for the use in the diagnosing and immunotherapy of oncological diseases
Belarusian Research Center for Pediatric Oncology, Hematology & Immunology, Borovlyany, Republic of Belarus
Vestnik VGMU. 2022;21(6):29-37.
Abstract.
Intercellular relationships are the basis of the physiological and pathological biochemical processes in the organism, and recent advances in exosome (Exo) research helped to reveal the mechanism of intercellular exchange of information. Furthermore, the functional properties of extracellular vesicles are being actively investigated nowadays, this opens up great perspectives for their using in clinical practice. Numerous investigations demonstrated the applicability of exosomes for targeted drug delivery. Exosomes play an important role in cancer and they contain the genetic material not only of normal cells of the organism, but also of tumor cells. Therefore, the analysis of exosomes from peripheral blood may be more efficient and specific for the non-invasive diagnosing of cancer. Moreover, exosomes from immune cells possess the immunomodulating activity and can be used in antitumor immunotherapy.
Keywords: exosomes (Eхо), therapeutic use, oncology, tumor’s exosomes, immunotherapy, targeted therapy.
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Information about authors:
Y.V. Savich – associate officer, Belarusian Research Center for Pediatric Oncology, Hematology & Immunology,
E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Yuliya V. Savich;
Y.I. Isaikina – Candidate of Biological Sciences, head of the laboratory, Belarusian Research Center for Pediatric Oncology, Hematology & Immunology;
M.A. Novikova – research officer, Belarusian Research Center for Pediatric Oncology, Hematology & Immunology.
