Menu

A+ A A-

Download article

DOI: https://doi.org/10.22263/2312-4156.2023.2.80

A.Ya. Efremova, M.L. Pivavar, M.N. Sabodina
Using 3D technologies to design the elements of analytical equipment and its maintenance
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus

Vestnik VGMU. 2023;22(2):80-89.

Abstract.
Objectives. To evaluate the possibility of manufacturing individual spare parts, consumables and tools for analytical equipment by stereolithographic 3D printing.
Material and methods. The photopolymer printer Anycubic Photon was chosen as a 3D printer to ensure high accuracy and durability of the printed models. To create, refine and print the models, Autodesk Fusion 360 CAD program, Meshmixer editor program and Photon Workshop slicer program were used. For printing we used universal resins Anycubic Basic and Voxelab Standard Photopolymer Resin, urethane-acrylate resin eSUN Hard-Tough Resin with increased toughness and flexible urethane-acrylate resin eSUN eResin-Flex.
Results. Development and printing of objects passed the following stages: creation of three-dimensional digital model of the object using CAD-softwares; export of the created 3D model in STL-format, and its revision in editor software; choice of printing method and materials; creation of a set of instructions for 3D printer in slicer software, the selection of printing conditions; preparation of 3D printer for work; post-processing of the product. Chromatograph fittings installation tool, covers with inserts for the mobile phase tank, 10-32 and ¼-28 threaded syringe-capillary adapters, glass filter adapters, mobile phase filters, chromatography column plugs, syringe plugs, adapters for measuring pressure in low pressure gas lines, tool for installing high-voltage wires of the capillary electrophoresis system were printed using additive technologies.
Conclusions. Digital models were developed and spare parts and consumables for various analytical equipment were printed. The surface structure of the obtained samples was smooth enough to ensure tightness of the joints and did not require post-processing. At the same time, it was found that in contact with methanol and acetonitrile, in products made of the used plastics quickly enough brittleness appeared or there was a noticeable swelling, making it difficult or impossible to use the printed products. This fact indicates the need for additional research on the properties of photopolymer resins before using the parts obtained from them in a particular analytical equipment.
Keywords: 3D printing, additive technologies, parametric modeling, liquid chromatography, ICP-MS, capillary electrophoresis.

References

1. Shkuro AE, Krivonogov PS. 3D printing technologies and materials: ucheb posobie. Ekaterinburg, RF: Ural gos lesotekhn un-t; 2017. 1 elektron opt disk (CD-ROM). Zagl s ekrana. To zhe. Rezhim dostupa: http://elar.usfeu.ru/bitstream/123456789/6617/1/Shkuro.pdf. Data dostupa: 20.03.2023. (In Russ.)
2. Malaev IA, Pivovar ML. Additive Technologies: Applications in Medicine and Pharmacy. Vestn Farmatsii. 2019;(2):98-107. (In Russ.)
3. Babkin OE. 3D modeling: technology, equipment, materials. St. Petersburg, RF: Izd-vo SPbGUKiT; 2013. 97 р. (In Russ.)
4. Alekseev KV, Blynskaya EV, Tishkov SV, Alekseev VK, Ivanov AA. Modifications of additive technologies for the production of dosage forms. Ros Bioterapevt Zhurn. 2020;19(1):13-21. (In Russ.)
5. Sergeev GK. Development of a 3D-printed plastic joint prosthesis and bone substitute material. V: Tyumen gos med un-t; Medvedeva IV, Petrov IM, Solov'ev GS, Panteleev SM, red. Aktual'nye problemy teoreticheskoi, eksperimental'noi, klinicheskoi meditsiny i farmatsii: materialy 52-i ezhegod vseros konf studentov i molodykh uchenykh, Tyumen', 12 apr 2018 g. Tyumen, RF; 2018. Р. 347. (In Russ.)
6. Manero A, Smith P, Sparkman J, Dombrowski M, Courbin D, Kester A, et al. Implementation of 3D Printing Technology in the Field of Prosthetics: Past, Present, and Future. Int J Environ Res Public Health. 2019 May;16(9):1641. doi: http://dx.doi.org/10.3390/ijerph16091641
7. Yanagi Y, Nakayama K, Taguchi T, Enosawa S, Tamura T, Yoshimaru K, et al. In vivo and ex vivo methods of growing a liver bud through tissue connection. Sci Rep. 2017 Oct 26;7(1):14085. doi: http://dx.doi.org/10.1038/s41598-017-14542-2
8. Albritton JL, Miller JS. 3D bioprinting: improving in vitro models of metastasis with heterogeneous tumor microenvironments. Dis Model Mech. 2017 Jan;10(1):3-14. doi: http://dx.doi.org/10.1242/dmm.025049
9. Ertesyan AR, Sadykov MI, Nesterov AM. Overview of 3D printing technologies in dentistry. Med-farmatsevt Zhurn Pul's. 2020;22(10):15-8. (In Russ.)
10. Li FS. Using 3D technology in dentistry. V: Cheremisin AB, red. Dostizheniya i perspektivy razvitiya molodezhnoi nauki: sb st Mezhdunar nauch-prakt konf, Petrozavodsk, 25 dek 2019 g. Petrozavodsk, RF: MTsNP Novaya nauka; 2019. Р. 440-4. (In Russ.)
11. Roshchin VS, Kanatov AV, Storozhev VV. 3D modeling methods using modern computer technology. V: Mosk gos un-t dizaina i tekhnologii; Balykhin MG, Oleneva OS, Vinogradova YuV, Rybaulina IV, Razumeev KE, Kirsanova EA, red. Innovatsionnoe razvitie legkoi i tekstil'noi promyshlennosti (INTEKS-2015): vseros nauch studench konf, 14-16 apr 2015 g: sb materialov. Ch 2. Moscow, RF; 2015. Р. 61-2. (In Russ.)
12. Polontsov SM. Rapid prototyping technologies in modern manufacturing. Nauch Al'm. 2020;(4-1):58-9. (In Russ.)
13. Maltseva OV. Development of the global 3D printer market. Ros Vneshneekonom Vestn. 2018;(9):88-97. (In Russ.)

Information about authors:
A.Ya. Efremova – the fifth-year pharmaceutical student, Vitebsk State Order of Peoples’ Friendship Medical University, https://orcid.org/0000-0002-3302-1794
e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Anna Ya. Efremova;
M.L. Pivavar – Candidate of Pharmaceutical Sciences, associate professor of the Chair of Toxicological & Analytical Chemistry, Vitebsk State Order of Peoples’ Friendship Medical University, https://orcid.org/0000-0003-4287-813X
M.N. Sabodina – Candidate of Chemical Sciences, associate professor of the Chair of Toxicological and Analytical Chemistry, Vitebsk State Order of Peoples’ Friendship Medical University, https://orcid.org/0000-0002-2678-4523

Поиск по сайту