DOI: https://doi.org/10.22263/2312-4156.2023.3.55
K.V. Nikitsina1, G.V. Ilukevich2
Clinical and laboratory assessment of systemic inflammatory response syndrome in patients with acute severe pancreatitis
1Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
2Belarusian Medical Academy of Postgraduate Education, Minsk, Republic of Belarus
Vestnik VGMU. 2023;22(3):55-62.
Abstract.
Objectives. To study and give a clinical and laboratory assessment of the systemic inflammatory response in patients with acute severe pancreatitis.
Material and methods. The severity of the course of the disease, the dynamics of the leukocyte formula indicators, leukocyte intoxication index (LII), C-reactive protein (CRP), procalcitonin (PCT) in 79 patients at various stages of acute pancreatitis were analyzed. Depending on the severity of the disease, 3 groups were identified: group 1 – 12 patients with mild course, group 2 – 32 patients with moderate severity course, group 3 – 35 patients with severe course of pancreatitis.
Results. It was proved that the severe course of acute pancreatitis already at an early stage of the disease was characterized by high rates of CRP, PCT, LII, leukocytes and rod-shaped neutrophils in combination with lymphopenia, the dynamics of changes in which further correlated with the degree of endogenous intoxication and the severity of the acute pancreatitis course, assessed using the integral scales of Ranson, Imre, Balthazar, APACHE II, SAPS, SOFA, Marshall, MODS.
Conclusions. In acute pancreatitis, systemic inflammatory response syndrome develops, various degree of the intensity of which depends on the stage and severity of the disease. There is a close relationship between the indicators of the leukocyte formula, LII, CRP and PCT with the intensity of endogenous intoxication syndrome and the severity of the disease.
Keywords: acute severe pancreatitis, leukocyte formula, leukocyte intoxication index, C-reactive protein, procalcitonin, Ranson, Imre, Balthazar, APACHE II, SAPS, SOFA, Marshall, MODS scales.
Acknowledgements. The authors express their gratitude to anonymous reviewers.
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Information about authors:
K.V. Nikitsina – Candidate of Medical Sciences, associate professor, head of the Chair of Anesthesiology and Resuscitation with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University, https://orcid.org/0000-0003-4744-6838,
e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Katsyaryna V. Nikitsina;
G.V. Ilukevich – Doctor of Medical Sciences, professor, head of the Chair of Anesthesiology and Resuscitation, Belarusian Medical Academy of Postgraduate Education, https://orcid.org/0000-0002-3474-621X
