DOI: https://doi.org/10.22263/2312-4156.2023.4.21
V.M. Bondarenko1, S.I. Pimanov1, E.V. Makarenko1, E.F. Bondarenko2
Metabolically healthy obesity: factors influencing stability and prognosis
1Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
2Vitebsk Regional Clinical Hospital, Vitebsk, Republic of Belarus
Vestnik VGMU. 2023;22(4):21-32.
Abstract.
Obesity has traditionally been considered as a significant risk factor for cardiovascular diseases and metabolic disorders. However, there are significant differences between obese patients in terms of the number of associated metabolic disorders and the risk of complications development. Finding out the reason for the formation of different obesity phenotypes (metabolically healthy and unhealthy) is the goal of numerous studies. The influence of genetic factors and lifestyle of obese patients on clinical outcomes has been established. The question of whether metabolically healthy obesity (MHO) is a benign condition remains a matter of ongoing debate. It has been observed that the risk of developing cardiovascular diseases and type 2 diabetes mellitus in people with MHO is higher than that in metabolically healthy subjects with normal body weight. The results of meta-analyses and prospective studies have shown that over time, a significant proportion of patients with MHO develops diseases that are characteristic of individuals with metabolically unhealthy obesity. For this reason, MHO can be viewed as a transient phenotype with the transformation into a metabolically unhealthy variant with the lapse of time.
Keywords: metabolically healthy obesity, metabolically unhealthy obesity, cardiovascular diseases, diabetes mellitus, cardiometabolic risk, visceral adipose tissue, genetic factors, diet, cardiorespiratory endurance.
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Information about authors:
V.M. Bondarenko – Candidate of Medical Sciences, associate professor of the Chair of Hospital Surgery with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University,
e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Vladimir M. Bondarenko;
S.I. Pimanov – Doctor of Medical Sciences, professor, head of the Chair of Internal Diseases & Ultrasound Diagnostics of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University;
E.V. Makarenko – Doctor of Medical Sciences, professor of the Chair of Internal Diseases & Ultrasound Diagnostics of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University;
E.F. Bondarenko – anesthesiologist-resuscitator, Vitebsk Regional Clinical Hospital.
