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DOI: https://doi.org/10.22263/2312-4156.2023.5.34

M.U. Kuncevicz, S.M. Yermashkevich, V.I. Petukhov
The assessment of the pituitary-gonadal axis in males with acute infectious lung destructions
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus

Vestnik VGMU. 2023;22(5):34-45.

Abstract.
Objectives. To study the state of the pituitary-gonadal axis in males with acute infectious lung destructions (AILD).
Material and methods. 80 males with AILD requiring surgical treatment and 30 healthy male volunteers were examined. The study considered the clinical forms and complications of AILD, the scoring of the severity of the lung purulent-destructive process, the duration of the course of the disease, and the age of the patients. The content of the luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin and total testosterone in blood serum was determined to assess the pituitary-gonadal axis. The obtained data were processed using the methods of descriptive and non-parametric statistics.
Results. The serum levels of LH, FSH, total testosterone decreased and serum levels of prolactin increased proportionally the severity of the disease in males with AILD (rS=-0.32; p=0.004; rS=-0.29; p=0.01; rS=-0.38; p=0.00043 and rS=0.30; p=0.007, respectively). Androgenic status in males with AILD had a direct moderate correlation with the severity of the lung purulent-destructive process (rS=0.37; p=0.0007), as well as a moderate inverse correlation with the duration of the disease (rS=-0.40; p=0.0002) and was not associated with patients’ age (rS=0.06; p=0.61). Androgen deficiency was diagnosed in 78% (95% CI: 68–87) of males with AILD requiring surgery. Hypergonadotropic androgen deficiency was found in 9% (95% CI: 3-15) of males with AILD, normogonadotropic – in 64% (95% CI: 53-75), hypogonadotropic – in 5% (95% CI: 0-10). Androgen deficiency was found more often and passed worse during the first 4 weeks of the disease in males with AILD.
Conclusions. The obtained data should be taken into account in diagnosing testosterone deficiency and planning androgen replacement therapy in males with AILD.
Keywords: acute infectious lung destructions, luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, total testosterone, androgen deficiency.

Information about the source of support in the form of grants, equipment, drugs: The investigations were carried out within the framework of the theme «To develop and implement a set of measures for the diagnosis and treatment of metabolic disorders in acute infectious lung destructions» (State Registration №20190175 dated 14.03.2019, implementation date 2019–2021) task 3.39 of subprogram 3 «New technologies for the treatment of diseases» of the State Program for Scientific Research (SPSR) «Fundamental and applied sciences for medicine», funded by the Ministry of Health of the Republic of Belarus in 2019–2020, and task 4.3.17 of subprogram 4.3 «Innovative technologies in clinical medicine» SPSR 4 «Translational Medicine», funded by the Ministry of Health of the Republic of Belarus in 2021.

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Information about authors:
M.U. Kuncevicz – Candidate of Medical Sciences, associate professor of the Chair of Hospital Surgery with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University, https://orcid.org/0000-0002-8122-6655
e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Maksim U. Kuncevicz;
S.M. Yermashkevich – Candidate of Medical Sciences, associate professor of the Chair of Hospital Surgery with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University, https://orcid.org/0000-0002-0866-9070
V.I. Petukhov – Doctor of Medical Sciences, professor of the Chair of Hospital Surgery with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University, https://orcid.org/0000-0002-4042-3978

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