DOI: https://doi.org/10.22263/2312-4156.2023.6.9
V.M. Semenov1, T.I. Dmitrachenko1, S.K. Ziankova1, S.K. Yahorau1, I.A. Lyatos1, A.A. Marchenko1, A.N. Kizimenka1, K.A. Savochkina1, T.A. Aksinushkina1, A.M. Kashtanov2
Clinical and pathogenetic significance of TTV infection
1Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
2Vitebsk Regional Clinical Hospital, Vitebsk, Republic of Belarus
Vestnik VGMU. 2023;22(6):9-17.
Abstract.
The review provides information on torque teno virus (TTV), discovered in 1997 by a group of Japanese researchers. In recent years, it has been established that TTV is found with high frequency in patients with various diseases and in healthy population. As virological, epidemiological studies and clinical observations have been conducted, views on the role of TTV in humans have evolved. The first ideas about the hepatotropic nature of TTV have changed, information about the polytropism of the virus has appeared, which refutes its attribution only to viruses that cause the development of hepatitis. The established high prevalence of TTV in the human population has allowed some researchers to suggest the possibility of persistence of this virus in the body as a part of the virome. Particular interest in TTV is due to the fact that this virus may be a marker of the immune dysfunction, indicating immune suppression after solid organ transplantation and a number of human diseases. In this regard, the results of studies on the timing and routes of its penetration into the human body, the possibility of vertical transmission of TTV from mother to child, and the dynamics of the viral load in patients with various pathologies are important.
Keywords: torque teno virus (TTV), epidemiology, pathogenesis.
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Information about authors:
V.M. Semenov – Doctor of Medical Sciences, professor, head of the Chair of Infectious Diseases with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University, E-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Valery M.Semenov;
T.I. Dmitrachenko – Doctor of Medical Sciences, professor of the Chair of Infectious Diseases with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University;
S.K. Ziankova – Candidate of Medical Sciences, associate professor of the Chair of Infectious Diseases with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University;
S.K. Yahorau – Candidate of Medical Sciences, associate professor of the Chair of Infectious Diseases with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University;
I.A. Lyatos – Candidate of Medical Sciences, associate professor, head of the Military Chair, Vitebsk State Order of Peoples’ Friendship Medical University;
A.A. Marchenko – lecturer of the Chair of Ophthalmology, Vitebsk State Order of Peoples’ Friendship Medical University;
A.N. Kizimenka – Candidate of Medical Sciences, associate professor of the Chair of Anesthesiology and Resuscitation with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University;
K.A. Savochkina – lecturer of the Chair of Infectious Diseases with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University;
T.A. Aksinushkina – senior lecturer of the Military Chair, Vitebsk State Order of Peoples’ Friendship Medical University;
A.M. Kashtanov – deputy chief physician for medical affairs, Vitebsk Regional Clinical Hospital.
