DOI: https://doi.org/10.22263/2312-4156.2024.1.40
V.M. Bondarenko, S.I. Pimanov, E.V. Makarenko
Correlation of the triglycerides level and sex hormones in the blood serum with the amount of visceral adipose tissue in patients with erectile dysfunction
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2024;23(1):40-48.
Abstract.
Objectives. To establish the correlation between the amount of visceral adipose tissue (VAT) of various localization and the level of triglycerides and sex hormones in the blood serum of patients with erectile dysfunction (ED).
Material and method. 47 men with ED aged Me (25; 75) 52.0 (44.0; 55.0) years were examined. All subjects filled in the International Index of Erectile Function (IIEF-5) questionnaire. The criterion for the presence of ED was less than 20 points decrease in the IIEF-5 scale score. Ultrasound examination to measure the value of VAT of various localization was carried out on a Logiq E9 device (GE Healthcare, USA) with convex 4.0 MHz and linear 10.0 MHz sensors. The intima-media thickness of the carotid arteries was also assessed. The level of serum testosterone, prolactin, estradiol, follicle-stimulating and luteinizing hormones was determined by means of radioimmunoassay.
Results. A moderate negative correlation was established between the content of testosterone in the blood serum and the amount of intra-abdominal visceral adipose tissue (r=–0.517; p<0.001) and the area of the lower part of the perirenal adipose tissue (r=–0.417; p=0.004), as well as a weak negative correlation between the level of serum testosterone with the value of epicardial visceral adipose tissue (r=–0.326; p=0.025) and left intima-media thickness (r=–0.379; p=0.009). No association was found between ultrasound indicators of the amount of adipose tissue and the content of estradiol, prolactin, follicle-stimulating and luteinizing hormones in the blood serum. A positive correlation of moderate strength was found between the content of triglycerides in the blood serum and the amount of intra-abdominal (r=0.609; p<0.001) and pericardial visceral adipose tissue (r=–0.501; p<0.001), as well as the area of the lower part of perirenal adipose tissue (r=0.415; p=0.008).
Conclusions. There is a weak negative correlation between serum testosterone levels and a moderate positive correlation between serum triglyceride levels and the amount of visceral adipose tissue.
Keywords: erectile dysfunction, visceral adipose tissue, triglycerides, testosterone.
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Information about authors:
V.M. Bondarenko – Candidate of Medical Sciences, associate professor of the Chair of Hospital Surgery with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University,
e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Vladimir M. Bondarenko;
S.I. Pimanov – Doctor of Medical Sciences, professor, head of the Chair of Internal Diseases & Ultrasound Diagnostics of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University;
E.V. Makarenko – Doctor of Medical Sciences, professor of the Chair of Internal Diseases & Ultrasound Diagnostics of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University.
