DOI: https://doi.org/10.22263/2312-4156.2024.3.88
M.A. Kryshtopava, A.B. Bizunkov, V.A. Nesterenko
First experience of using intranasal spray based on hyaluronic acid after planned surgical interventions in the nasal cavity, paranasal sinuses and nasopharynx
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2024;23(3):88-96.
Abstract.
Objectives. To evaluate the efficacy and safety of using intranasal spray based on hyaluronic acid at the postoperative stage in patients after planned sinonasal and nasopharyngeal surgeries.
Material and methods. A prospective observational study was performed according to the protocol of open, uncontrolled, non-randomized trial in patients after surgery in the nasal cavity, paranasal sinuses and nasopharynx in the early postoperative period (n=18). All patients used nasal spray 3 times a day during 10 days. We assessed the efficacy (an investigator and a patient); product reliability (an investigator); comfort of use (an investigator); safety (an investigator); informativeness of the instructions for use (an investigator). The data were analysed using nonparametric statistics method.
Results. The study of the clinical course of postoperative rhinitis showed that the nasal spray in patients after sinonasal and nasopharyngeal surgeries (n=16) was effective (3 points), safe (3 points) and reliable (3 points). The conformity of the medication appearance (3 points), comfort of use (3 points), informativeness of the instructions for use (3 points) were determined. During the study, no cases of intolerance or unexpected adverse drug reactions were detected.
Conclusions. The nasal spray with hyaluronic acid may be used in medical practice in order to improve the regeneration of the nasal mucosa in patients after the sinonasal and nasopharyngeal surgeries. The use of this medication in the acute phase of the postoperative period is the reasonable pathophysiological approach to the treatment.
Keywords: intranasal spray, nasal cavity, paranasal sinuses, nasopharynx, post-traumatic inflammation, hyaluronic acid.
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Submitted 07.02.2024
Accepted 14.06.2024
Information about authors:
M.A. Kryshtopava – Candidate of Medical Sciences, associate professor, head of the Chair of Otorhinolaringology, Vitebsk State Order of Peoples’ Friendship Medical University;
A.B. Bizunkov – Candidate of Medical Sciences, associate professor of the Chair of Otorhinolaringology, Vitebsk State Order of Peoples’ Friendship Medical University,
e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Alexander B. Bizunkov;
V.A. Nesterenko – senior lecturer of the Chair of General and Clinical Pharmacology with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University; head of clinical research center of the VSMU Clinic.
