DOI: https://doi.org/10.22263/2312-4156.2024.4.31
V.A. Malatok, S.E. Rzheussky, R.V. Krauchanka, I.A. Vasilchuk
The study of antimicrobial action of medical foam based on aluminum chloride
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2024;23(4):31-36.
Abstract.
One of the promising directions in the development of drugs used in surgery is their improvement by giving them additional antimicrobial properties. The purpose of this work was to evaluate the presence of an antibacterial effect in a medical hemostatic foam based on aluminum chloride. The study was carried out on museum strains of Shigella sonnei ATCC 29930, Bacillus cereus ATCC 11778, Enterococcus faecalis ATCC 29212, Proteus vulgaris ATCC 6380, Bifidobacterium bifidum ATCC 11853, Escherichia coli ATCC 25922, Klebsiella pneumonia ATCC 13883, Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Staphylococcus epidermidis ATCC 12228, in relation to which the minimum inhibitory concentration and minimum bactericidal concentration were determined. It has been established that medical hemostatic foam based on aluminum chloride possesses antimicrobial properties against gram-positive and gram-negative museum strains of microorganisms, in contrast to the sample that does not contain the active substance. It has been determined that the minimum inhibitory concentration for gram-positive and gram-negative microorganisms does not differ. However, it has been revealed that medical hemostatic foam based on aluminum chloride has a more pronounced bactericidal effect against gram-negative microorganisms. The minimum bactericidal concentration of the developed drug corresponded to the minimum inhibitory concentration against three strains of microorganisms (Shigella sonnei ATCC 29930, Bacillus cereus ATCC 11778, Klebsiella pneumonia ATCC 13883). The antimicrobial effect of medical hemostatic foam based on aluminum chloride is weak in comparison with that of antiseptic drugs available on the pharmaceutical market and cannot be used as the main action. However, it allows us to assume a safe course of surgical intervention with a lower likelihood of infectious complications development.
Keywords: aluminum chloride, medical foam, antimicrobial effect, pharmaceutical development, minimum inhibitory concentration, museum strains.
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Submitted 30.05.2024
Accepted 28.08.2024
Information about authors:
V.A. Malatok – postgraduate of the Chair of Organization & Economy of Pharmacy, Vitebsk State Order of Peoples’ Friendship Medical University,
e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Veranika A. Malatok;
S.E. Rzheussky – Candidate of Pharmaceutical Sciences, associate professor of the Chair of Organization & Economy of Pharmacy, Vitebsk State Order of Peoples’ Friendship Medical University;
R.V. Krauchanka – lecturer of the Chair of Pathologic Physiology, Vitebsk State Order of Peoples’ Friendship Medical University;
I.A. Vasilchuk – senior lecturer of the Chair of Organization & Economy of Pharmacy, Vitebsk State Order of Peoples’ Friendship Medical University.
