DOI: https://doi.org/10.22263/2312-4156.2024.4.9
Yu.G. Tsuran
Premature rupture of membranes: prognosis, features of obstetrics tactics
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2024;23(4):9-21.
Abstract.
Premature rupture of membranes (PROM) is a common obstetric complication, occurring in 10-19% of cases of term labor and in 25-54% of preterm labor. This obstetric situation is one of the important problems of modern obstetrics, as it affects obstetric and neonatal outcomes. PROM in full-term pregnancy causes not only complications of childbirth and the postpartum period, but it is a risk factor for a newborn’s disease, especially the development of infectious and inflammatory complications.
Premature birth in 30-56% of women begins with prelabor rupture of the amniotic membranes. The morphofunctional immaturity of the fetus, high frequency of intrauterine hypoxia and infection can cause high perinatal morbidity and mortality in premature babies with this complication of pregnancy.
The research topic is not studied fully in the domestic and foreign scientific community. At the same time, the optimal choice of the management of labor with PROM is the key to maintaining the health of the future generation. However, with all the variety of applied tactics and clinical recommendations devoted to the management of patients with PROM, a method for preparing the cervix that gives 100% result has not been developed yet. None of the methods is without drawbacks in terms of effectiveness, contraindications for use, invasiveness for the fetus, and prevention of complications in this pathology. Many of the applied methods enable the prediction of only the general outcome of pregnancy, without allowing to assess the fetus condition, and take into account the indicators characterized by significant individual variability, that can have a major impact on the reliability of the results obtained.
Today, there are no clear-cut criteria for the diagnosis and prognosis of the severity of fetal intrauterine infection (IUI), pregnancy management tactics and the time of delivery in case of premature rupture of membranes. The search for an optimal way to solve these issues was the reason for conducting this literature review.
Keywords: pregnancy, premature rupture of membranes, preterm labor, urgent labor.
References
1. Astafyev VV, Nazarova SV, Li AD, Podzolkova NM. Current status of the problem of premature amniotic fluid shedding in preterm pregnancy (literature review). Arkh Akusherstva Ginekologii im VF Snegireva. 2017;4(4):187-93. (In Russ.). doi: http://dx.doi.org/10.18821/2313-8726-2017-4-4-187-193
2. ACOG Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 80: premature rupture of membranes. Clinical management guidelines for obstetrician-gynecologists. Obstet Gynecol. 2007 Apr;109(4):1007-19. doi: http://dx.doi.org/10.1097/01.AOG.0000263888.69178.1f
3. Diguisto C. Term Prelabor Rupture of Membranes: CNGOF Guidelines for Clinical Practice – Definition, Epidemiology, Complications and Risk Factors. Gynecol Obstet Fertil Senol. 2020 Jan;48(1):19-23. doi: http://dx.doi.org/10.1016/j.gofs.2019.10.016
4. Mynarek M, Bjellmo S, Lydersen S, Strand KM, Afset JE, Andersen GL, et al. Prelabor rupture of membranes and the association with cerebral palsy in term born children: a national registry-based cohort study. BMC Pregnancy Childbirth. 2020 Jan;20(1):67. doi: http://dx.doi.org/10.1186/s12884-020-2751-3
5. Premature rupture of the fetal membranes. Prenatal discharge of amniotic fluid: klin protokol diagnostiki i lecheniya № 181: odobren Ob"edin komis po kachestvu med uslug M-va zdravookhraneniya Respubliki Kazakhstan ot 26 maya 2023 g. V: MedElement [Internet]. Available from: https://diseases.medelement.com/disease/%D0%BF%D1%80%D0%B5%D0%B6%D0%B4%D0%B5%D0%B2%D1%80%D0%B5%D0%BC%D0%B5%D0%BD%D0%BD%D1%8B%D0%B9-%D1%80%D0%B0%D0%B7%D1%80%D1%8B%D0%B2-%D0%BF%D0%BB%D0%BE%D0%B4%D0%BD%D1%8B%D1%85-%D0%BE%D0%B1%D0%BE%D0%BB%D0%BE%D1%87%D0%B5%D0%BA-%D0%B4%D0%BE%D1%80%D0%BE%D0%B4%D0%BE%D0%B2%D0%BE%D0%B5-%D0%B8%D0%B7%D0%BB%D0%B8%D1%82%D0%B8%D0%B5-%D0%BE%D0%BA%D0%BE%D0%BB%D0%BE%D0%BF%D0%BB%D0%BE%D0%B4%D0%BD%D1%8B%D1%85-%D0%B2%D0%BE%D0%B4-%D0%BA%D0%BF-%D1%80%D0%BA-2023/17654. [Accessed 28th June 2024]. (In Russ.)
6. Induction of labor: klin protokol med vmeshatel'stva № 177: odobren Ob"edin komis po kachestvu med uslug M-va zdravookhraneniya Respubliki Kazakhstan ot 13 yanv 2023 g. V: MedElement [Internet]. Available from: https://diseases.medelement.com/disease/%D0%B8%D0%BD%D0%B4%D1%83%D0%BA%D1%86%D0%B8%D1%8F-%D1%80%D0%BE%D0%B4%D0%BE%D0%B2-%D0%BA%D0%BF-%D1%80%D0%BA-2022/17523. [Accessed 28th June 2024]. (In Russ.)
7. Bodykov GZh, Bishchekova BN, Koldasbaeva AS, Kabyl BK. Features of the course of labor in prenatal rupture of fetal membranes. Farmatsiya Kazakhstana. 2017;(4):40-3. (In Russ.)
8. Timokhina EV, Lebedev VA, Karpova AM, Kurbanzade PF, Mikheeva MV. Premature rupture of fetal membranes in premature pregnancy. Management tactics: reality and prospects. Arkh Aakusherstva Ginekologii im VF Snegireva. 2021;8(2):93-100. (In Russ.). doi: http://dx.doi.org/10.17816/2313-8726-2021-8-2-93-100
9. Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 188: Prelabor Rupture of Membranes. Obstet Gynecol. 2018 Jan;131(1):e1-e14. doi: http://dx.doi.org/10.1097/AOG.0000000000002455
10. Finnström O, Olausson PO, Sedin G, Serenius F, Svenningsen N, Thiringer K, et al. The Swedish national prospective study on extremely low birthweight (ELBW) infants. Incidence, mortality, morbidity and survival in relation to level of care. Acta Paediatr. 1997 May;86(5):503-11. doi: http://dx.doi.org/10.1111/j.1651-2227.1997.tb08921.x
11. Di Renzo, GC. The great obstetrical syndromes. J Matern Fetal Neonatal Med. 2009 Aug;22(8):633-5. doi: http://dx.doi.org/10.1080/14767050902866804
12. Lorthe E, Ancel PY, Torchin, Kaminski M, Langer B, Subtil D, et al. Impact of latency duration on the prognosis of preterm infants after preterm premature rupture of membranes at 24 to 32 weeks’ gestation: a national population-based cohort study. J Pediatr. 2017 Mar:182:47-52. doi: http://dx.doi.org/10.1016/j.jpeds.2016.11.074
13. Vsemir org zdravookhraneniya. Born too soon. Report on global action on preterm births. [B m]: VOZ; 2014. 126 р. (In Russ.)
14. Siegler Y, Weiner Z, Solt I. ACOG Practice Bulletin No. 217: Prelabor Rupture of Membranes. Obstet Gynecol. 2020 Nov;136(5):1061. doi: http://dx.doi.org/10.1097/AOG.0000000000004142
15. Yasmina A, Barakat A. Prelabour rupture of membranes (PROM) at term: prognostic factors and neonatal consequence. Pan Afr Med J. 2017 Feb:26:68. doi: http://dx.doi.org/10.11604/pamj.2017.26.68.11568
16. Bolotskikh VM. Premature amniotic fluid shedding: theory and practice. St. Petersburg, RF: Eko-Vektor; 2018. 191 р. (In Russ.)
17. Oboskalova TA, Maksimyak OV. Premature rupture of fetal membranes in preterm pregnancy. Ros Vestn Akushera-ginekologa. 2021;21(1):54-60. (In Russ.). doi: http://dx.doi.org/10.17116/rosakush20212101154
18. Baena-García L, Marín-Jiménez N, Romero-Gallardo L, Borges-Cosic M, Ocón-Hernández O, Flor-Alemany M, et al. Association of Self-Reported Physical Fitness during Late Pregnancy with Birth Outcomes and Oxytocin Administration during Labour-The GESTAFIT Project. Int J Environ Res Public Health. 2021 Aug;18(15):8201. doi: http://dx.doi.org/10.3390/ijerph18158201
19. Bapaeva GB, Dzhamanaeva KB, Chuvakova TK, Kulbaeva SN. Premature prenatal rupture of fetal membranes in premature pregnancy: a literature review. Nauka Zdravookhranenie. 2015;(3):17-28. (In Russ.)
20. Kan NE, Tyutyunnik VL, Kesova MI, Donnikov AE. Current understanding of connective tissue dysplasia. Klin Eksperim Khirurgiya Zhurn im akad BV Petrovskogo. 2016;4(1):44-50. (In Russ.)
21. Fadeeva TS, Molokanova MV, Pavlov OG. Influence of the severity of undifferentiated connective tissue dysplasia on the course of pregnancy Bulletin of New Medical Technologies. Vestn Novykh Med Tekhnologii [Internet]. 2019;(3). Available from: https://www.elibrary.ru/item.asp?id=38241312. [Accessed 23th August 2024]. (In Russ.)
22. Saryeva OP, Peretyatko LP, Vakhromeev AP, Pareyshvili VV. Pathomorphology of extraplacental membranes in premature rupture and undifferentiated connective tissue dysplasia in women. Arkh Patologii. 2019;81(4):26-32. (In Russ.). doi: http://dx.doi.org/10.17116/patol20198104126
23. Kotomina TS, Kokaya IYu. Microbial landscape in premature rupture of fetal membranes. Mosk Meditsina. 2016;(spets vyp 1):137. (In Russ.)
24. Kuznetsova NB, Bushtyreva IO, Dmitrieva MP, Barinova VV, Dybova VS. Local cytokine profile in women with preterm labor due to premature rupture of fetal membranes. Reproduktiv Zdorov'e Vostoch Evropa. 2019;9(6):684-93. (In Russ.)
25. Mikhaylov AV, Dyatlova LI, Rogozhina IE, Glukhova TN, Panina OS. Management of pregnancy complicated by premature amniotic fluid shedding in premature pregnancy. Akusherstvo Ginekologiya. 2014;(2):67-73. (In Russ.)
26. Thakur VS, Liang YW, Lingappan K, Jiang W, Wang L, Barrios R, et al. Increased susceptibility to hyperoxic lung injury and alveolar simplification in newborn rats by prenatal administration of benzo[a]pyrene. Toxicol Lett. 2014 Oct;230(2):322-32. doi: http://dx.doi.org/10.1016/j.toxlet.2014.03.006
27. Nikolaeva MG, Serdyuk GV. Undifferentiated connective tissue dysplasia as a risk factor for premature rupture of fetal membranes at 22-36 weeks gestation. Sovrem Meditsina: aktual. voprosy. 2013;(22):18-28. (In Russ.)
28. Knyazeva TP. Causes and risk factors for premature rupture of the fetal membranes. Dal'nevostoch Med Zhurn. 2016;(2):128-135. (In Russ.)
29. Guseynova GE, Khodzhaeva ZS. Clinical and anamnestic features of women with premature rupture of fetal membranes in preterm labor. Akusherstvo Ginekologiya. 2019;(8):54-61. (In Russ.). doi: http://dx.doi.org/10.18565/aig.2019.8.54-61
30. Kuznetsova NB, Bushtyreva IO, Dybova VS, Barinova VV, Dmitrieva MP. Etiology and pathogenesis of premature rupture of fetal membranes in premature pregnancy. Vest Nats Mediko-khirurg Tsentra im NI Pirogova. 2019;14(4):57-61. (In Russ.). doi: http://dx.doi.org/10.25881/BPNMSC.2020.32.74.012
31. Musilova I, Andrys C, Drahosova M, Zednikova B, Hornychova Helena, Pliskova L, et al. Late preterm prelabor rupture of fetal membranes: fetal inflammatory response and neonatal outcome. Pediatr Res. 2018 Mar;83(3):630-37. doi: http://dx.doi.org/10.1038/pr.2017.300
32. Schmitz T, Sentilhes L, Lorthe E, Gallot D, Madar H, Doret-Dion M, et al. Preterm premature rupture of the membranes: Guidelines for clinical practice from the French College of Gynaecologists and Obstetricians (CNGOF). Eur J Obstet Gynecol Reprod Biol. 2019 May:236:1-6. doi: http://dx.doi.org/10.1016/j.ejogrb.2019.02.021
33. Mysorekar IU, Cao B. Microbiome in parturition and preterm birth. Semin Reprod Med. 2014 Jan;32(1):50-5. doi: http://dx.doi.org/10.1055/s-0033-1361830
34. Brubaker L, Wolfe AJ. The Female Urinary Microbiota/Microbiome: Clinical and Research Implications. Rambam Maimonides Med J. 2017 Apr;8(2):e0015. doi: http://dx.doi.org/10.5041/RMMJ.10292
35. Gulersen M, Zottola C, Li X, Krantz D, DiSturco M, Bornstein E. Chorioamnionitis after premature rupture of membranes in nulliparas undergoing labor induction: prostaglandin E2 vs. oxytocin. J Perinat Med. 2021 Jun 9;49(9):1058-63. doi: http://dx.doi.org/10.1515/jpm-2021-0094
36. Kim CJ, Romero R, Chaemsaithong P, Kim JS. Chronic inflammation of the placenta: definition, classification, pathogenesis, and clinical significance. Am J Obstet Gynecol. 2015 Oct;213(4 Suppl):S53-69. doi: http://dx.doi.org/10.1016/j.ajog.2015.08.041
37. Aagaard K, Ganu R, Ma J, Riehle K, Petrosino J, Versalovic J. Whole metagenomic shotgun sequencing reveals a vibrant placental microbiome harboring metabolic function. Am J Obstetrics Gynecol. 2013 Jan;208(S5). doi: http://dx.doi.org/10.1016/j.ajog.2012.10.182
38. Chaemsaithong P, Romero R, Korzeniewski SJ, Martinez-Varea A, Dong Z, Yoon BH, et al. A rapid interleukin-6 bedside test for the identification of intra-amniotic inflammation in preterm labor with intact membranes. J Matern Fetal Neonatal Med. 2016;29(3):349-59. doi: http://dx.doi.org/10.3109/14767058.2015.1006620
39. Romero R, Miranda J, Kusanovic JP, Chaiworapongsa T, Chaemsaithong P, Martinez A, et al. Clinical chorioamnionitis at term I: microbiology of the amniotic cavity using cultivation and molecular techniques. J Perinat Med. 2015 Jan;43(1):19-36. doi: http://dx.doi.org/10.1515/jpm-2014-0249
40. Combs CA, Garite TJ, Lapidus JA, Lapointe JP, Gravett M, Rael J, et al. Detection of microbial invasion of the amniotic cavity by analysis of cervicovaginal proteins in women with preterm labor and intact membranes. Am J Obstet Gynecol. 2015 Apr;212(4):482.e1-482.e12. doi: http://dx.doi.org/10.1016/j.ajog.2015.02.007
41. Theis KR, Romero R, Winters AD, Greenberg JM, Gomez-Lopez N, Alhousseini A, et al. Does the human placenta delivered at term have a microbiota? Results of cultivation, quantitative real-time PCR, 16S rRNA gene sequencing, and metagenomics. Am J Obstet Gynecol. 2019 Mar;220(3):267.e1-267.e39. doi: http://dx.doi.org/10.1016/j.ajog.2018.10.018
42. Dutta EH, Behnia F, Boldogh I, Saade GR, Taylor BD, Kacerovský M, et al. Oxidative stress damage-associated molecular signaling pathways differentiate spontaneous preterm birth and preterm premature rupture of the membranes. Mol Hum Reprod. 2016 Feb;22(2):143-57. doi: http://dx.doi.org/10.1093/molehr/gav074
43. Remneva OV, Kolyado OV, Pesotskaya AV, Starodubtsev EG, Gumenyuk IS. Pathomorphologic features of postpartum in patients with different clinical phenotypes of spontaneous preterm labor. Akusherstvo Ginekologiya. 2021;(8):111-18. (In Russ.). doi: http://dx.doi.org/10.18565/aig.2021.8.111-118
44. Menon R, Moore JJ. Fetal Membranes, Not a Mere Appendage of the Placenta, but a Critical Part of the Fetal-Maternal Interface Controlling Parturition. Obstet Gynecol Clin North Am. 2020 Mar;47(1):147-62. doi: http://dx.doi.org/10.1016/j.ogc.2019.10.004
45. Dobrokhotova YuE, Trofimov DYu, Shchegolev AI, Burmenskaya OV, Veselovskaya YuS, Mitrofanova YuV, i dr. Peculiarities of progesteronin-induced blocking factor gene mRNA expression in the placenta in preterm labor. Akusherstvo Ginekologiya. 2017;(7):62-7. (In Russ.). doi: http://dx.doi.org/10.18565/aig.2017.7.62-7
46. Artymuk NV, Elizarova NN. Risk factors for premature rupture of fetal membranes in women with preterm labor in Kemerovo Oblast. Fundam Klin Meditsina. 2016;1(2):6-11. (In Russ.)
47. Dyatlova LI, Ermolaeva EI, Glukhova TN. Significance of cytokine profile changes in the pathogenesis of premature rupture of fetal membranes in premature pregnancy. Innovats Nauka. 2015;(11-3):218-21. (In Russ.)
48. Nizyaeva NV, Karapetyan AO, Gapaeva MD, Prikhodko AM, Sinitsyna VA, Baev OR. Increased angiogenesis as a factor contributing to fetal membrane rupture in physiologic pregnancy and in preterm labor. Geny Kletki. 2019;14(3 pril):164-5. (In Russ.)
49. Gomez-Lopez N, Romero R, Panaitescu B, Miller D, Zou C, Gudicha DW, et al. Gasdermin D: in vivo evidence of pyroptosis in spontaneous labor at term. J Matern Fetal Neonatal Med. 2021 Feb;34(4):569-79. doi: http://dx.doi.org/10.1080/14767058.2019.1610740
50. Kondratyuk DV, Rybalka AN, Shlapak IM, Sulima AN. Etiopathogenesis and prevention of premature rupture of fetal membranes. Tavricheskii Mediko-biol Vestn. 2018;21(2-2):174-81. (In Russ.)
51. Baev OR, Dikke G. Diagnostika prezhdevremennogo razryva plodnykh obolochek na osnovanii biokhimicheskikh testov. Akusherstvo Ginekologiya. 2018;(9):132-6. (In Russ.). doi: http://dx.doi.org/10.18565/aig.2018.9.132-136
52. Maki Y, Furukawa S, Nakayama T, Oohashi M, Shiiba N, Furuta K, et al. Clinical chorioamnionitis criteria are not sufficient for predicting intra-amniotic infection. J Matern Fetal Neonatal Med. 2022 Jan;35(1):52-57. doi: http://dx.doi.org/10.1080/14767058.2020.1711725
53. Maki Y, Furukawa S, Kodama Y, Sameshima H, Ikenoue T. Amniocentesis for threatened preterm labor with intact membranes and the impact on adverse outcome in infants born at 22 to 28 weeks of gestation. Early Hum Dev. 2015 May;91(5):333-7. doi: http://dx.doi.org/10.1016/j.earlhumdev.2015.03.006
54. Romero R, Chaemsaithong P, Docheva N, Korzeniewski SJ, Kusanovic JP, Yoon BH, et al. Clinical chorioamnionitis at term VI: acute chorioamnionitis and funisitis according to the presence or absence of microorganisms and inflammation in the amniotic cavity. J Perinat Med. 2016 Jan;44(1):33-51. doi: http://dx.doi.org/10.1515/jpm-2015-0119
55. Caloone J, Rabilloud M, Boutitie F, Traverse-Glehen A, Allias-Montmayeur F, Denis L, et al. Accuracy of several maternal seric markers for predicting histological chorioamnionitis after preterm premature rupture of membranes: a prospective and multicentric study. Eur J Obstet Gynecol Reprod Biol. 2016 Oct:205:133-40. doi: http://dx.doi.org/10.1016/j.ejogrb.2016.08.022
56. Mikhaylova OV, Ionov OV, Antonov AG, Nikitina IV, Degtyareva AV, Levadnaya AV, i dr. Diagnostic value of procalcitonin and C-reactive protein in congenital infections in extremely low and very low birth weight infants. Pediatr Farmakologiya. 2015;12(4):422-8. (In Russ.). doi: http://dx.doi.org/10.15690/pf.v12i4.1423
57. Clinical protocol "Medical supervision and medical care of women in obstetrics and gynecology": postanovlenie M-va zdravookhraneniya Resp Belarus', 20 fevr 2018 g, № 17: v red postanovleniya M-va zdravookhraneniya Resp Belarus' ot 09.02.2024 g. V: Nats tsentr pravovoi inform Resp Belarus'. Etalon [Elektronnyi resurs]. Minsk, RB; 2024. (In Russ.)
58. Khamadyanov UR, Gumerova IA, Khamadyanova AU, Galimov AI, Khamadyanova SU, Tikhonova TF. Pathogenetic aspects and perinatal outcomes in prenatal rupture of fetal membranes. Med Vestn Bashkortostana. 2015;10(6):88-92. (In Russ.)
59. Pintucci A, Meregalli V, Colombo P, Fiorilli A. Premature rupture of membranes at term in low risk women: how long should we wait in the "latent phase"? J Perinat Med. 2014 Mar;42(2):189-96. doi: http://dx.doi.org/10.1515/jpm-2013-0017
60. Mirkuzie AH, Sisay MM, Bedane MM. High proportions of obstetric referrals in Addis Ababa: the case of term premature rupture of membranes. BMC Res Notes. 2016 Jan:9:40. doi: http://dx.doi.org/10.1186/s13104-016-1852-6
61. Gupta S, Malik S, Gupta S. Neonatal complications in women with premature rupture of membranes (PROM) at term and near term and its correlation with time lapsed since PROM to delivery. Trop Doct. 2020 Jan;50(1):8-11. doi: http://dx.doi.org/10.1177/0049475519886447
62. Sibiude J. Term Prelabor Rupture of Membranes: CNGOF Guidelines for Clinical Practice – Timing of Labor Induction. Gynecol Obstet Fertil Senol. 2020 Jan;48(1):35-47. doi: http://dx.doi.org/10.1016/j.gofs.2019.10.015
63. Herbst A, Källén K. Time between membrane rupture and delivery and septicemia in term neonates. Obstet Gynecol. 2007 Sep;110(3):612-8. doi: http://dx.doi.org/10.1097/01.AOG.0000277632.36186.84
64. Padayachee L, Kale M, Mannerfeldt J, Metcalfe A. Oral Misoprostol for Induction of Labour in Term PROM: A Systematic Review. J Obstet Gynaecol Can. 2020 Dec;42(12):1525-31. doi: http://dx.doi.org/10.1016/j.jogc.2020.02.111
65. Devillard E, Delabaere A, Rouzaire M, Pereira B, Accoceberry M, Houlle C, et al. Induction of labour in case of premature rupture of membranes at term with an unfavourable cervix: protocol for a randomised controlled trial comparing double balloon catheter (+oxytocin) and vaginal prostaglandin (RUBAPRO) treatments. BMJ Open. 2019 Jun;9(6):e026090. doi: http://dx.doi.org/10.1136/bmjopen-2018-026090
66. Budilovskaya OV, Shipitsyna EV, Pereverzeva NA, Vorobyeva NE, Spasibova EV, Grigoryev AN, i dr. Comparison of methods for assessing the inflammatory response of the lower female reproductive tract. Zhurn Akusherstva Zhen Boleznei. 2018;67(5):13-20. (In Russ.)
Submitted 08.05.2024
Accepted 28.08.2024
Information about authors:
Yu. G. Tsuran – lecturer of the Chair of Obstetrics and Gynecology, Vitebsk State Order of Peoples’ Friendship Medical University,
e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Yuliya G. Tsuran.
