DOI: https://doi.org/10.22263/2312-4156.2024.5.112
S.L. Achinovich1, T.N. Nesterovich2, O.N. Ganusevich1, A.N. Frolov1, P.A. Bibikov1
Morphological diagnosis of lung cancer against the background of hamartoma
1Gomel Regional Clinical Oncological Dispensary, Gomel, Republic of Belarus
2Gomel State Medical University, Gomel, Republic of Belarus
Vestnik VGMU. 2024;23(5):112-118.
Abstract.
Objectives. To analyze the data of clinical studies and discuss an interesting clinical case of morphological diagnosis of lung cancer against the background of hamartoma.
Material and methods. Publications were searched in eLibrary, CyberLeninka, Scopus, Web of Science, PubMed, Google Scholar in English and Russian. The articles published between 2016 and 2023 were selected for analysis.
Results. A 66-year-old patient was diagnosed with a lung tumor, which is of interest in terms of the complexity of morphological differential diagnosis. The neoplasm described had to be differentiated between primary micropapillary lung adenocarcinoma, metastasis of the papillary thyroid cancer, metastasis of serous carcinoma of the ovary and malignant hamartoma. The immunohistochemical study was conducted followed by the molecular genetic testing. A rare case of the lung adenocarcinoma of the micropapillary structure, grade 3 arising within chondromatous hamartoma with foci of osteoformation was identified in the patient.
Conclusions. Thus, the presented clinical case demonstrates a rare histological type of micropapillary adenocarcinoma of the lung against the background of hamartoma. The focal mass in the lung was detected using radiological diagnostic methods. However, a comprehensive morphological study including immunohistochemical study and molecular genetic testing was required to identify the process.
Keywords: lung cancer, malignant hamartoma of the lung, morphological diagnosis, immunohistochemical study, molecular genetic testing.
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Submitted 28.11.2023
Accepted 18.10.2024
Information about authors:
S.L. Achinovich – head of the pathology department, Gomel Regional Clinical Oncological Dispensary, https://orcid.org/0000-0002-0977-5481
T.N. Nesterovich – lecturer of the Chair of Oncology, Gomel State Medical University, https://orcid.org/0000-0001-5692-1042
e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Tatyana Nikolaevna Nesterovich;
O.N. Ganusevich – oncologist-surgical of the oncology department №6, Gomel Regional Clinical Oncological Dispensary, https://orcid.org/0000-0003-2202-2254
A.N. Frolov – radiologist of the X-ray department, Gomel Regional Clinical Oncological Dispensary;
P.A. Bibikov – head of the X-ray department, Gomel Regional Clinical Oncological Dispensary.
