DOI: https://doi.org/10.22263/2312-4156.2024.6.19
O.Y. Poluliakh
Effects of viral infections on the brain function
Institute of Physiology of the National Academy of Sciences of Belarus, Minsk, Republic of Belarus
Vestnik VGMU. 2024;23(6):19-30.
Abstract.
The results of epidemiological studies indicate an increase in mental and neurodevelopmental disorders during viral pandemics, which suggests a possible role of viruses in the etiology of these disorders.
Objectives. To elucidate the role of viral infections in the pathogenesis of neuropsychiatric disorders on the basis of current literature data.
This review considers a number of issues, including nervous system diseases initiated by viral infection; interactions between the immune system and the brain; and the impact of viral infections on neurotransmission.
Disorders of central nervous system functions develop both through direct exposure of the virus to the brain and through the immune system, including activation of toll-like receptors with subsequent production of pro-inflammatory cytokines and impaired neurotransmitter interaction.
Keywords: viral infections, neuropsychiatric disorders, immune system, cytokines, neurotransmitters, neurodevelopment.
Acknowledgments. The author expresses sincere gratitude to her scientific adviser, Mityukova T.A., Candidate of Medical Sciences, associate professor, Chief Research Scientist of Institute of Physiology of the National Academy of Sciences of Belarus for help in writing and revising this article.
The sources of funding. The task is “To study the state of mental health, the brain functional state, the pro-inflammatory and autoimmune status of children who have had COVID infection, and to identify markers of the CNS disorders associated with COVID infection” within the framework of the State Program of Scientific Research “Translational Medicine” for 2021-2025, the subprogram “Experimental Medicine”.
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Submitted 19.08.2024
Accepted 04.12.2024
Information about authors:
Olga Y. Poluliakh – Senior Researcher, Institute of Physiology of the National Academy of Sciences of Belarus,
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