DOI: https://doi.org/10.22263/2312-4156.2024.6.40
I.A. Piatsko, A.K. Usovich, S.D. Tolstaya
Morphometric analysis of age-related changes in the prostate vascular network
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2024;23(6):40-46.
Abstract.
Objectives. To analyze the age-related changes of morphometric parameters of the vascular network in various structural zones of the prostate gland and their relationship with indicators of extraorgan vessels.
Material and Methods. Blood vessels were examined on the autopsy material from 47 men distributed into three age groups (22-35 years, 36-60 years, and 61-75 years). Structural and morphometric changes in the prostate intraorgan arteries, veins, capillaries in its different zones and prostate periorgan arteries and veins were studied using histological and morphometric methods. Results were processed using STATISTICA 10 software package.
Results. Age-related changes in the vascular network of the prostate gland were found to be zone-specific. A decrease in capillary density, thickening of vessel walls, and an increase in venous diameter were observed with advancing age. In elderly men (61–75 years), pronounced degenerative changes were noted, including the development of paravasal fibrosis and tissue hypoxia. For prostate periorgan arteries and veins, a moderate correlation has been established between age and their internal diameter, as well as the thickness of their walls.
Conclusions. The age-related changes in the prostate vascular network while maintaining well-known patterns and involution stages are zone-specific.
Keywords: prostate, vascular network, age-related changes, microcirculation, benign prostatic hyperplasia, morphometry.
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Submitted 25.09.2024
Accepted 04.12.2024
Information about authors:
I.A. Piatsko – Candidate of Biological Sciences, associate professor of the Chair of Human Anatomy, Vitebsk State Order of Peoples’ Friendship Medical University,
e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Iryna A. Piatsko;
A.K. Usovich – Doctor of Medical Sciences, professor of the Chair of Human Anatomy, Vitebsk State Order of Peoples’ Friendship Medical University;
S.D. Tolstaya – senior lecturer of the Chair of of Internal Diseases & Ultrasound Diagnostics of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University.
