DOI: https://doi.org/10.22263/2312-4156.2024.6.47
L.I. Bondareva, L.R. Vykhrystenka
Assessment of urine and blood serum peptides in proliferative and non-proliferative forms of primary chronic glomerulonephritis
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2024;23(6):47-54.
Abstract.
Objectives. To determine serum and urine proteins in patients with proliferative and non–proliferative forms of primary chronic glomerulonephritis (CGN); to identify their relationship with indicators of renal function.
Material and methods. The study included 41 patients aged 19-62 years with primary CGN, group 1 - patients (n=29) with proliferative forms of CGN, group 2 (n=12) with nephroliferative forms. General clinical parameters were assessed as well as the estimated glomerular filtration rate (eGFR), the content of immunoglobulins (Ig) A, G, M, levels of transforming growth factor beta (TFR-β), interleukin (IL) – 10 in blood serum, transferrin, alpha-1-microglobulin (α-1-MG) and beta-2-microglobulin (β-2-MG) in urine.
Results. Intergroup differences in the content of total serum protein, cholesterol, daily proteinuria, IgA and IgG were revealed. In patients of group 1, there was a direct correlation between the level of α-1-MG in urine and the level of daily proteinuria and serum creatinine, the reverse – with the level of eGFR. In group 2, the level of β-2 MG of urine was associated with creatinemia and inversely correlated with a decrease in eGFR. As hematuria increased in proliferative CGN, the level of IL-10 increased, in non-proliferative forms the levels of α-1-MG, β-2-MG and urine transferrin increased, while the level of TFR-β blood serum decreased.
Conclusions. The levels of α-1-MG, β-2-MG and transferrin of urine, IL-10 and TFR-β of blood serum can be considered as potential biomarkers determining the differences between proliferative and non-proliferative forms of primary CGN.
Keywords: chronic primary glomerulonephritis, estimated glomerular filtration rate, IgA, IgG, IgM, transforming growth factor beta, interleukin-10, transferrin, alpha-1-microglobulin, beta-2-microglobulin.
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Submitted 09.07.2024
Accepted 04.12.2024
Information about authors:
L.I. Bondareva – senior lecturer of the Chair of General Medical Practice, Vitebsk State Order of Peoples’ Friendship Medical University,
e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – L.I. Bondareva;
L.R. Vykhrystsenka – Doctor of Medical Sciences, professor, head of the Chair of General Medical Practice, Vitebsk State Order of Peoples’ Friendship Medical University.
