DOI: https://doi.org/10.22263/2312-4156.2024.6.55
A.S. Aleksandrovich
Assessment of the endothelial cell desquamation degree in the blood of pregnant women at increased risk of fetoplacental insufficiency
Grodno State Medical University, Grodno, Republic of Belarus
Vestnik VGMU. 2024;23(6):55-62.
Abstract.
Objectives. To analyze the number of circulating endothelial cells (CEC) in the blood of pregnant women for investigating the pathogenetic mechanisms of diagnosing fetoplacental insufficiency.
Material and methods. In the course of this study, a two-step analysis procedure was carried out. At the initial stage of the study, women with fetoplacental insufficiency predisposition participated. Their CEC levels were measured at various stages of pregnancy. At the second stage, CEC levels were compared in pregnant women with regular physical activity (at least 150 minutes per week) and in women of the control group who did not exercise.
Results. The given study revealed that the CEC level in all the examined groups significantly exceeded the standard values (8-10×104 cells per 1 liter of plasma). The highest values of the CEC level were observed during the 12th-16th weeks of pregnancy. In pregnant women at risk with regular physical activity, the median CEC level was 27.80×104 per 1 liter of plasma, which is significantly lower than in the control group (41.90×104 per 1 liter of plasma). A statistically significant difference between the groups (p<0.05) indicates a positive effect of physical activity on the vascular endothelium state.
Conclusions. An increased level of circulating endothelial cells (CEC) indicates the endothelium dysfunction and can be considered as an early marker of the fetoplacental insufficiency. Regular physical activity helps to reduce the CEC level in pregnant women at risk for fetoplacental insufficiency. This is due to the improvement of the vascular endothelium state and, as a result, a decreased risk of this complication development.
Keywords: fetoplacental insufficiency, circulating endothelial cells, physical activity, pregnancy, endothelial dysfunction.
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Submitted 11.10.2024
Accepted 04.12.2024
Information about authors:
Aleksandrovich Aliaksandr Sulejmanovich – Candidate of Medical Sciences, Associate Professor, Head of the Chair of Radiation Diagnostics, Grodno State Medical University, https://orcid.org/0000-0003-4679-4937, e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра..
