DOI: https://doi.org/10.22263/2312-4156.2024.6.63
E.S. Kavaleva1, A.L. Lipnitski1,2, А.V. Marochkov1,2, E.V. Karaleva2
Hyperphosphatemia as a pathological syndrome in critically ill patients
1Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
2Mogilev Regional Clinical Hospital, Mogilev, Republic of Belarus
Vestnik VGMU. 2024;23(6):63-69.
Abstract.
Objectives. To determine the impact of hyperphosphatemia on the treatment outcomes of critically ill patients.
Material and methods. A single-center retrospective non-randomized observational study was conducted, which included all patients with hyperphosphatemia (n=444) undergoing intensive care in the anesthesiology and intensive care departments over the 10-month period in 2023.
Results. The highest phosphorus levels were observed in patients with nephrological (1.89 (1.64; 2.24) mmol/l), hematological (1.85 (1.65; 2.1) mmol/l) and pulmonary pathologies (1.81 (1.6; 2.3) mmol/l). The phosphorus level in deceased patients with hyperphosphatemia (n=116 (26.1%)) was statistically significantly higher than in surviving patients: 1.78 (1.60; 2.18) mmol/l and 1.67 (1.54; 1.95) mmol/l, respectively, p=0.015. The cutoff point for the phosphorus level in predicting mortality in critically ill patients with baseline hyperphosphatemia was 1.99 mmol/l with a sensitivity of 38.8% and a specificity of 77.8% (AUC=0.577 (SE 0.031, 95% CI 0.53-0.624, p=0.013)).
Conclusions. The incidence of hyperphosphatemia among patients in the anesthesiology and intensive care units was 14.7%, and among all hospital patients – 4.7%.
Keywords: hyperphosphatemia, phosphates, inorganic phosphorus, intensive care, mortality.
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Submitted 28.10.2024
Accepted 04.12.2024
Information about authors:
E.S. Kavaleva – a 6th year student of the General Medicine Faculty, Vitebsk State Order of Peoples’ Friendship Medical University, https://orcid.org/0009-0007-1335-4958
A.L. Lipnitski – Candidate of Medical Sciences, head of the department for coordination of taking organs and tissues for transplantation, Mogilev Regional Clinical Hospital; associate professor of the affiliated branch of the Chairs of Anesthesiology and Resuscitation with the course of the Faculty for Advanced Training & Retraining and Hospital Surgery with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University, https://orcid.org/0000-0002-2556-4801, e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Artur L. Lipnitski;
A.V. Marochkov – Doctor of Medical Sciences, professor, anesthesiologist-resuscitator of the anesthesiology and resuscitation department, Mogilev Regional Clinical Hospital; professor of the branch of the Chairs of Anesthesiology & Resuscitation and Hospital Surgery with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University, https://orcid.org/0000-0001-5092-8315
E.V. Karaleva – laboratory diagnostics doctor of the centralized laboratory of clinical biochemistry, Mogilev Regional Clinical Hospital, https://orcid.org/0009-0008-9837-8031
