DOI: https://doi.org/10.22263/2312-4156.2025.1.35
T.V. Levkovich1, T.P. Pronko1, A.S. Babenka2
Parameters of arterial remodeling in men with arterial hypertension when carrying polymorphic variants of the transforming growth factor β1 gene
1Grodno State Medical University, Grodno, Republic of Belarus
2Scientific and Practical Centre “Cardiology”, Minsk, Republic of Belarus
Vestnik VGMU. 2025;24(1):35-45.
Abstract.
Introduction. Arterial remodeling in arterial hypertension (AH) occurs with the participation of transforming growth factor β1 (TGFβ1).
Objectives. To evaluate the parameters of arterial remodeling and the level of TGFβ1 in men with AH of I and II degree in carriage of polymorphic variants C(-509)T, T869C, G915C of the TGFB1 gene.
Material and methods. 65 practically healthy men aged 30-49 years were included in the group I and 139 patients with grade I-II of AH – in the group II. Arterial remodeling parameters were determined using VaSera VS-1500N sphygmograph, Impekard-M rheograph, and SonoScape S20Exp ultrasound device. Genotyping for the polymorphic variants C(-509)T, T869C, G915C of the TGFB1 gene was performed using the polymerase chain reaction method. The TGFβ1 level was determined using the enzyme immunoassay method.
Results. In group I, the cardio-ankle vascular index (CAVI) and carotid-radial pulse wave velocity (crPWV) were higher in the carriage of the CC genotype of the C(-509)T polymorphic variant (p=0,04 and p=0,01 respectively), and the CAVI was lower in the carriage of the TT genotype of the T869C polymorphic variant (p=0,02). No differences were found in the analysis of the incidence of pathological and borderline indicators of CAVI, pathological augmentation index, crPWV, carotid intima-media thickness in patients with AH when carrying polymorphic variants of the gene.
Conclusions. In practically healthy individuals carrying the CC genotype of the C(-509)T polymorphic variant, higher parameters of CAVI and crPWV are detected, and in those carrying the TT genotype of the T869C polymorphic variant, lower CAVI results are detected, while in patients with AH the arterial remodeling parameters are comparable.
Keywords: transforming growth factor β1, arterial remodeling, cardio-ankle vascular index, arterial hypertension.
Acknowledgments. The authors express their sincere gratitude to Olga Vladimirovna Gorchakova, head of the scientific and production section of the Department of Preclinical and Experimental Research of the Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus for her assistance in isolating genomic DNA.
The sources of funding. The study was carried out with the financial support of the Belarusian Republican Foundation for Fundamental Research within the project M23-078.
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Submitted 06.11.2024
Accepted 11.02.2025
Information about authors:
T.V. Levkovich – senior lecturer of the Chair of Internal Diseases Propaedeutic, Grodno State Medical University, https://orcid.org/0000-0003-1305-3657
e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра. – Tatyana V. Levkovich;
T.P. Pronko – Candidate of Medical Sciences, associate professor of the Chair of Internal Diseases Propaedeutic, Grodno State Medical University, https://orcid.org/0000-0003-2126-5246
A.S. Babenka – Candidate of Chemical Sciences, biologist of the Clinical-diagnostic Laboratory, Scientific and Practical Centre “Cardiology”, https://orcid.org/0000-0002-5513-970X
