DOI: https://doi.org/10.22263/2312-4156.2025.3.66
V.A. Hizemava1, S.V. Kapatsevich2, P.D. Dziameshka1
Gamma Knife radiosurgery outcomes in patients with the brain arteriovenous malformations in the Republic of Belarus
1N.N. Alexandrov National Cancer Center of Belarus, Minsk, Republic of Belarus
2Republican Research and Clinical Center of Neurology and Neurosurgery, Minsk, Republic of Belarus
Vestnik VGMU. 2025;24(3):66-75.
Abstract.
Objectives. To analyze the stereotactic radiosurgery outcomes in patients with the cerebral arteriovenous malformations, taking into account the RBAS (radiosurgery-based AVM score) score.
Material and methods. The study included the data from 33 patients who underwent stereotactic radiosurgery on a Gamma Knife (Elekta, Sweden) for cerebral arteriovenous malformations in the N.N. Alexandrov National Cancer Center of Belarus from 2017 to 2024. The RBAS radiosurgery outcome prediction scale was used to forecast radiosurgery outcomes. The Kaplan-Meier method was used to calculate the cumulative incidence of the arteriovenous malformation obliteration and the median time to obliteration. Statistical analysis was performed using SPSS v.23.
Results. The RBAS score averaged 0.93±0.43. 20 (60.6%) patients had a score of 1.00 or less, 10 (30.3%) patients had a score of 1.01–1.50, and 3 (9.1%) patients had a score of 1.51–2.00. The cumulative incidence of complete obliteration confirmed by cerebral angiography was: 2-year 25.1±11.0%; 3-year 56.3%±16.2%; median time to obliteration was 37.0±9.2 months. Late radiation toxicity of grades II and III was 6.1% and 6.1%, respectively; the incidence of hemorrhage was 3%, and mortality was 3%.
Conclusions. According to the obtained data, stereotactic radiosurgery can be considered an effective and safe method for treating properly selected patients with the brain arteriovenous malformations. A long-term follow-up period and a large cohort of patients are needed for a detailed analysis of the radiosurgery results as one of the treatment options for this malformation.
Keywords: arteriovenous malformation, stereotactic radiosurgery, Gamma Knife, obliteration.
Acknowledgments. The authors express their gratitude to O.A. Novoselskaya, I.A. Shturo, P.I. Nikitenko.
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Submitted 05.02.2025
Accepted 13.06.2025
Information about authors:
Volha A. Hizemava – Candidate of Medical Sciences, radiation oncologist, radiology department №3, N.N. Alexandrov National Cancer Center of Belarus, https://orcid.org/0000-0002-9724-6925, e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра.;
S.V. Kapatsevich – Candidate of Medical Sciences, associate professor, Leading Researcher of the Neurosurgical Department, Republican Research and Clinical Center of Neurology and Neurosurgery;
P.D. Dziameshka – Doctor of Medical Sciences, professor, chief researcher of the laboratory of radiation therapy,
N.N. Alexandrov National Cancer Centre of Belarus, https://orcid.org/0000-0002-1324-3656
