DOI: https://doi.org/10.22263/2312-4156.2025.5.56
Y.S. Ladzik, S.M. Yermashkevich
Biochemical and hemostasiological risk indicators in surgical treatment of diabetic foot syndrome
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2025;24(5):56-66.
Abstract.
Objectives. To determine biochemical and hemostasiological risk indicators associated with the results of surgical treatment of diabetic foot syndrome (DFS).
Material and methods. The retrospective analysis of the examination and treatment results of 452 patients with DFS was performed. Surgical activity was 60,0%. Local interventions on the foot were performed in 48,2% of patients, of which 14,7% required a series of additional local interventions, and 6,4% ultimately had to resort to «high» amputation of the lower limb. Primary «high» amputations of the lower limb were used in 11,7% of cases, 26% of which developed complications from the stump, for which the patients were operated on.
Results and discussion. In surgical treatment of DFS, the risk indicators in the biochemical blood test and coagulogram for performing additional operations on the foot after local interventions are the following: C-reactive protein (CRP) >52,6 mg/L, fibrinogen>7,3 g/L; «high» lower limb amputation after local foot interventions: CRP>70,5 mg/L; primary «high» lower limb amputation: urea >8,4 mmol/L, CRP>45,7 mg/L, prothrombin time (PT)>13,1 sec; «high» lower limb amputation during treatment: urea>6,3 mmol/L, high-density lipoproteins≤0,9 mmol/L, CRP>53 mg/L, PT>11.4 sec, fibrinogen>7.55 g/L; the need to perform additional surgical interventions after «high» amputation of the lower limb: activated partial thromboplastin time≤32 sec.
Conclusions. The obtained information can be used to predict the results and determine the rational tactics of surgical treatment in patients with diabetic foot syndrome.
Keywords: diabetic foot syndrome, surgical treatment, local interventions on the foot, amputation, reamputation, risk factors, prognosis.
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Submitted 14.05.2025
Accepted 21.10.2025
Information about authors:
Yulia S. Ladzik – postgraduate, lecturer of the Chair of Hospital Surgery with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University, https://orcid.org/0000-0002-5563-0275, e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра.;
S.M. Yermashkevich – Candidate of Medical Sciences, associate professor of the Chair of Hospital Surgery with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University, https://orcid.org/0000-0002-0866-9070
