DOI: https://doi.org/10.22263/2312-4156.2025.5.9
A.V. Bialiauski, Е.S. Pashinskaya, V.V. Pabiarzhyn
The role of circadian rhythms in the host-parasite system
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2025;24(5):9-16.
Abstract.
During evolution parasites have developed various mechanisms to enhance the success of host invasion, ensuring the survival of their species. In some parasites, this may involve a significant increase in the number of daughter cells, while in others; it may be an extremely high number of eggs released by a mature parasite. One of the most unique ways a parasite completes its life cycle is by manipulating the host’s behavioral responses, increasing the chances of transmission to an intermediate or definitive host. Typically, behavioral aspects of parasitic diseases are linked to the parasite’s direct influence on the central nervous system functions, though the exact mechanisms by which parasites alter neuronal activity remain largely unexplored. The environment in which a parasite resides within its host is shaped by numerous rhythmic processes. Circadian regulation of various physiological functions is known to be able to contribute to the course of parasitic diseases. The mammalian immune system exhibits daily rhythmicity, which is reflected in such parameters as immune cell transport and the inflammatory response to infection. Circadian control of immunity may enable animals to anticipate daily pathogenic threats from parasites and regulate the magnitude of the immune response, thereby optimizing their cellular defense. However, parasites themselves may have evolved to exploit the rhythmic processes of the host’s body to enhance their invasiveness. It is possible that circadian rhythmicity in parasites influences their ability to infect their hosts.
Keywords: parasites, parasitic diseases, circadian rhythms, behavior.
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Submitted 17.02.2025
Accepted 21.10.2025
Information about authors:
Aleg V. Bialiauski – postgraduate of the Chair of Infectious Diseases with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University, e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра.;
Е.S. Pashinskaya – Candidate of Biological Sciences, associate professor, Head of the Scientific and Educational Center “Center for Molecular Genetic and Biotechnological Research”, Vitebsk State Order of Peoples’ Friendship Medical University;
V.V. Pabiarzhyn – Candidate of Biological Sciences, associate professor, Dean of Overseas Students Training Faculty, Vitebsk State Order of Peoples’ Friendship Medical University.
