DOI: https://doi.org/10.22263/2312-4156.2025.6.37
E.V. Belaya1, G.L. Kozorez2, I.V. Pryzvan3, N.G. Solovyeva1, V.I. Tikhonova1, O.I. Shalak1, A.I. Klimovich4
Differentiated health-saving strategy for idiopathic scoliosis based on rs1107946 polymorphism genotype of the COL1A1 gene
1Belarusian State Pedagogical University named after Maxim Tank, Minsk, Republic of Belarus
217th City Children‘s Clinical Polyclinic, Minsk, Republic of Belarus
3Sanatorium Boarding School No. 9 of Minsk for Children with Diseases of the Musculoskeletal System and Connective Tissue, Minsk, Republic of Belarus
4Secondary School No. 226 of Minsk, Minsk, Republic of Belarus
Vestnik VGMU. 2025;24(6):37-46.
Abstract.
Objectives. To assess the association of the COL1A1 gene rs1107946 polymorphism with the risk of idiopathic scoliosis (IS) development and the effectiveness of conservative treatment in school-aged children for the development of a differentiated prevention and correction strategy.
Material and methods. A retrospective cohort study was conducted involving 166 girls and 76 boys with IS, and 104 participants in the control group. The prospective research part on the dynamics during standard treatment involved 67 children. Genotyping was performed by real-time PCR. Treatment effectiveness was assessed using computer optical topography and functional muscle tests.
Results. The CC genotype was found to be a risk factor for early onset of IS (6-8 years), especially in boys (OR=8.00; p=0.003). The A allele demonstrated a protective effect. The genotype modulated the response to treatment: carriers of the CA genotype showed better dynamics of deformity correction and a significant improvement in the strength endurance of back muscles (η²=0.270; p=0.038) compared to the CC genotype.
Conclusions. The COL1A1 gene rs1107946 polymorphism is a significant marker for stratifying the risk of early IS development and predicting the effectiveness of conservative treatment. Differentiated prevention and correction strategies for AA, CA, and CC genotypes have been developed based on the genotype.
Keywords: idiopathic scoliosis, COL1A1, rs1107946 polymorphism, genetic predisposition, personalized medicine, prevention.
Sources of funding. The work was carried out as part of the research project “Risks genetic evaluation of posture disorders in children and adolescents for creation health-saving educational environment”.
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Submitted 20.10.2025
Accepted 10.12.2025
Information about authors:
Elena V. Belaya – Doctor of Biological Sciences, associate professor, Professor of the Chair of Geography and Human Ecology, Belarusian State Pedagogical University named after Maxim Tank, https://orcid.org/0000-0003-1786-0341, e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра.;
G.L. Kozorez – traumatologist-orthopedist, head of the Department of Medical Care, 17th City Children‘s Clinical Polyclinic;
I.V. Pryzvan – teacher of physical education, instructor in exercise therapy, Sanatorium Boarding School No. 9 of Minsk for Children with Diseases of the Musculoskeletal System and Connective Tissue;
N.G. Solovyeva – head of the Chair of Biomedical Basics of Physical Education, Belarusian State Pedagogical University named after Maxim Tank, https://orcid.org/0009-0001-6627-5854
V.I. Tikhonova – senior lecturer of the Chair of Biomedical Basics of Physical Education, Belarusian State Pedagogical University named after Maxim Tank, https://orcid.org/0009-0003-7544-1716
O.I. Shalak – applicant for a Master’s degree, Belarusian State Pedagogical University named after Maxim Tank;
A.I. Klimovich – chemistry and biology teacher, Secondary School No. 226 of Minsk.
