DOI: https://doi.org/10.22263/2312-4156.2025.6.9
A.A. Malakhouskaya, N.I. Kiseleva
Modern opportunities for early prediction of preeclampsia (literature review)
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus
Vestnik VGMU. 2025;24(6):9-17.
Abstract.
Preeclampsia (PE) is a multifactorial hypertensive pathological condition that complicates the course of pregnancy in 2-8% of cases and is one of the main causes of perinatal and maternal morbidity and mortality in the world. PE is characterized by arterial hypertension that occurs in the second half of pregnancy in combination with proteinuria. Severe life-threatening complications of preeclampsia include eclampsia, HELLP syndrome, hematoma and rupture of the liver, pulmonary edema, acute renal failure, stroke, myocardial infarction, placental abruption, hemorrhages and retinal detachment. This syndrome is associated with fetoplacental insufficiency, premature birth, premature detachment of the normally located placenta, a large number of surgical deliveries, as well as bleeding during childbirth and the postpartum period. Early diagnosis and prevention of gestational complications are crucial not only for reducing maternal and infant morbidity and mortality, but also for reducing morbidity throughout a person’s life. However, despite the large amount of research, the heterogeneity of the mechanisms of the pathophysiology of PE makes it difficult to develop pathogenetically based methods for its early diagnosis and prevention at the preclinical stage.
Keywords: preeclampsia, biomarkers, Doppler ultrasonography, prediction model, endothelial dysfunction, screening algorithm, machine learning.
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Submitted 10.09.2025
Accepted 10.12.2025
Information about authors:
Alena A. Malakhouskaya – lecturer of the Chair of Obstetrics and Gynecology, Vitebsk State Order of Peoples’ Friendship Medical University, e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра.;
N.I. Kiseleva – Doctor of Medical Sciences, professor, head of the Chair of Obstetrics and Gynecology, Vitebsk State Order of Peoples’ Friendship Medical University.
