DOI: https://doi.org/10.22263/2312-4156.2026.1.41
N.M. Tsikhan1, S.A. Lialikau1, M.L. Hladki1, I.V. Parfenova1, E.V. Kotova2
Association of gene Il-10 polymorphisms with the risk of allergic rhinitis and recurrent wheezing manifestation in toddlers
1Grodno State Medical University, Grodno, Republic of Belarus
2Grodno University Clinic, Grodno, Republic of Belarus
Vestnik VGMU. 2026;25(1):41-48.
Abstract.
Objectives. To determine the frequency of alleles and genotypes of polymorphic variants of the IL-10 gene (G1082A, С592A, C819T) in children residing in Grodno region; to evaluate the association of these polymorphisms with the risk of developing allergic rhinitis and recurrent airway obstructions in toddlers.
Material and methods. 182 children from the prospective cohort study were observed for genetic polymorphisms of IL-10 gene: G1082A (rs1800896), С592A (rs1800872), C819T (rs1800871). 14 children with allergic rhinitis (AR) and 16 children with recurrent respiratory obstruction were included in the study group (SG). The rest of the evaluated (152/182) were included in the comparison group (CG).
Results. The relative risk (RR) for respiratory pathology manifestation in toddlers who are carriers more than 3 mutant alleles in polymorphisms G1082A, C592A and C819T was 2.10 (95% CI 1.08-4.08). The carrier frequency of more than 2 mutant alleles in G1082A and C592A polymorphisms in children with AR was 42.86%, in CG – 19.74% (p=0.03). The carrier frequency of more than 3 mutant alleles in the G1082A, C592A and C819T polymorphisms in toddlers with AR was 42.86%, in the CG – 16.45% (p=0.015). The RR for developing AR in toddlers who are carriers of 2 mutant alleles in G1082A and C592A polymorphisms or 3 mutant alleles in C592A, C819T and G1082A in combination with homozygous mutant genotype was 2.61 (95% CI 0.96-7.07) and 3.09 (95% CI 1.14-8.32) respectively.
Conclusions. The relative risk of an early manifestation of AR depends on the number of mutant alleles in the IL-10 gene polymorphisms (G1082A, C592A, C819T): the more mutant alleles, the higher risk of AR manifestation in toddlers is.
Keywords: allergic rhinitis, genetic polymorphism, first three years of life.
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Submitted 17.11.2025
Accepted 16.02.2026
Information about authors:
Natallia M. Tsikhan – Candidate of Medical Sciences, associate professor, head of the Pediatric Chair №1, Grodno State Medical University, https://orcid.org/0000-0002-7803-5460, e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра.;
S.A. Lialikau – Doctor of Medical Sciences, professor of the Clinical Laboratory Diagnostics and Immunology Chair, Grodno State Medical University, https://orcid.org/0009-0007-0085-0661
M.L. Hladki – assistant of the Normal Physiology Chair, Grodno State Medical University, https://orcid.org/0000-0001-9369-4977
I.V. Parfenova – Candidate of Medical Sciences, Associate Professor of the Pediatric Chair №1, Grodno State Medical University, https://orcid.org/0000-0001-5578-8833
E.V. Kotova – allergist, head of the allergy department, Grodno University Clinic.
