DOI: https://doi.org/10.22263/2312-4156.2026.2.43
A.D. Tahanovich, T.V. Ryabzeva, M.M. Kauhanka, A.V. Kolb
Compositional hemogram indices in patients with COPD
Belarusian State Medical University, Minsk, Republic of Belarus
Vestnik VGMU. 2026;25(2):43-54.
Abstract.
Objectives. To determine changes in composite hemogram indices, including serum C-reactive protein (CRP) and albumin concentrations in patients with COPD and to determine their relationship with the severity of pulmonary obstruction and the frequency of previous exacerbations during, before and after a treatment of the current exacerbation.
Material and Methods: Sixty-one patients diagnosed with COPD and 27 healthy controls were examined before the start of treatment and after 14 and 90 days correspondently. Cell count and ESR were determined in the venous blood samples, CRP and albumin levels were measured in the serum. The results were analyzed using nonparametric descriptive statistics.
Results. Severe obstruction (FEV₁<50%) gives the greatest increase in the NLR (neutrophils (Nf)/lymphocytes (Lf)), SII (Nf×platelets /Lf and SIRI (Nf x monocytes (Mon))/Lf indices, on average, 2-2.5 times higher than normal. Frequent exacerbations (≥2) even with relatively preserved respiratory function are accompanied by an increase (4.7 times higher than normal) in the CAR (C-reactive protein/Albumin) index. Moreover, it responds best to therapy, judging by its decrease. None of the markers of systemic inflammation (especially CAR and NLR) are completely normalized even 90 days after the start of treatment. During the treatment period (after 14 days), Pt/Mon demonstrates a decrease by 35%-40% mainly due to an increase of monocytes concentration.
Conclusions. The results of dynamic changes in NLR, SII, and SIRI support the hypothesis of chronic systemic inflammation in COPD that is resistant to standard therapy, the severity of which depends on both the degree of obstruction and the exacerbation phenotype.
Keywords: hemogram, indices, COPD, exacerbations, broncho-obstruction.
Acknowledgements. The authors express their deep appreciation and gratitude to the staff of the Department of Pulmonology and Surgical Treatment of Respiratory Diseases of the State Scientific and Practical Center for Pulmonology and Phthisiology of the Ministry of Health of the Republic of Belarus: MD, PhD, Assoc. Prof. Davidovskaya E.I., Bogush L.S., and Budnik O.A., MD, PhD., Head of the Clinical and Diagnostic Laboratory of the State Scientific and Practical Center for Pulmonology and Phthisiology of the Ministry of Health of the Republic of Belarus for their assistance in examining patients.
Sources of funding. The work was carried out with the financial support of the Ministry of Health of the Republic of Belarus within the framework of the State Program for Scientific Research 4 “Translational Medicine” (subprogram 4.2 “Fundamental Aspects of Medical Science”), task 4.2.44 “Determine the dynamics of changes in the content of proinflammatory proteins, cytokines, their receptors and cells in the blood of patients with chronic obstructive pulmonary disease”.
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Submitted 03.02.2026
Accepted 14 .04.2026
Information about authors:
Anatoliy D. Tahanovich – Doctor of Medical Sciences, professor, head of the Chair of Biological Chemistry, Belarusian State Medical University, https://orcid.org/0000-0002-0668-2888, e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра.;
T.V. Ryabzeva – Candidate of Biological Sciences, associate professor of the Chair of Biological Chemistry, Belarusian State Medical University;
M.M. Kauhanka – Candidate of Chemical Sciences, Associate Professor, head of the Chair of Biological Chemistry, Belarusian State Medical University, https://orcid.org/0000-0002-3193-5955
A.V. Kolb – Candidate of Biological Sciences, associate professor of the Chair of Biological Chemistry, Belarusian State Medical University.
