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DOI: https://doi.org/10.22263/2312-4156.2026.4.19

 

N.A. Kravchenko, E.S. Pashinskaya, V.V. Pobyarzhin, А.М. Khnykau
Influence of abiotic and biotic factors on the reproductive health of mammals
Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus

Vestnik VGMU. 2026;25(4):19-28.

Abstract.
The article presents information on the influence of abiotic and biotic environmental factors on gametogenesis. Common abiotic factors include environmental pollution, electromagnetic radiation, temperature, metal exposure, insecticides, and pesticides. Biotic factors include sexually transmitted infections, psychogenic factors, autoimmune diseases, and parasite metabolites. Among many factors, the products of their vital activity play a particularly important role. The influence of parasitic agents on the host's hereditary apparatus is rarely described in the literature. The problem of elucidating the role of parasitic infestations in altering the structure of genes controlling reproductive health, their activity, and the kinetics of processes associated with expression or repression remains unresolved. A promising and relevant area is the evaluation of biotic factors of a parasitic nature to optimize approaches to neutralizing their negative effects.

Keywords: gametogenesis, cohesin, meyosin, synaptonemal complex, Nanos, parasites.

References

  • 1. Lazareva NV, Lineva OI. Mechanisms of adverse influence of environmental factors on reproductive function, ways of correction. Zdorov’e i Obrazovanie v XXI veke. 2017;19(9):100-104. (In Russ.)
  • 2. World Health Organization. Infertility prevalence estimates, 1990−2021. Geneva: World Health Organization; 2023. URL: https://www.who.int/publications/i/item/978920068315 [Accessed 05th August 2026].
  • 3. Vsemirnaya organizatsiya zdravookhraneniya. WHO: One in six people worldwide is infertile. URL: https://www.who.int/ ru/news/item/04-04-2023-1-in-6-people-globally-affected-byinfertility [Accessed 05th August 2026]. (In Russ.).
  • 4. National Collaborating Centre for Women’s and Children’s Health. Fertility: assessment and treatment for people with fertility problems. London: Royal College of Obstetricians & Gynaecologists; 2013.
  • 5. Matach EA, Markevich AL. Male factor influence on reproductive loss. URL: https://medcenter.by/vlijaniemuzhskogo-faktora-na-reproduktivnye-poteri/ [Accessed 05th August 2026]. (In Russ.).
  • 6. Zhang JP, Meng QY, Wang Q, Zhang LJ, Mao YL, Sun ZX. Effect of smocing on semen quality of infertile men in Shandong, China. Asian Journal of Andrology. 2000 Jun;2(2):143-146.
  • 7. Dyubkova TP. The impact of tobacco use on women’s reproductive health. Meditsinskaya Panorama. 2006;(4):77- 81. (In Russ.).
  • 8. Cerami C, Founds H, Nicholl I, Mitsuhashi T, Giordano D, Vanpatten S, et al. Tobacco smoce is a sourse of toxic reactive glycation product. Proceedings of the National Academy of Sciences of the United States of America. 1997 Dec;94(25):13915-13920. doi: 10.1073/pnas.94.25.13915
  • 9. Geoffroy-Siraudin C, Perrard MH, Ghalamoun-Slaimi R, Ali S, Chaspoul F, Lanteaume A, et al. Ex-vivo assessment of chronic toxicity of low levels of cadmium on testicular meiotic cells. Toxicology and Applied Pharmacology. 2012 Aug;262(3):238-246. doi: 10.1016/j.taap.2012.04.033
  • 10. Patkin EL, Pavlinova LI, Sofronov GA. Effects of ecotoxics on mammalian embryogenesis and gametogenesis: epigenetic mechanisms. Biosfera. 2013;5(4):450-472. (In Russ.).
  • 11. Chigrinets SV, Bryukhin GV, Zavyalov SN. The morphological reproductive state of male white rats exposed to bisphenol A and triclozan. Zhurnal Anatomii i Gistopatologii. 2019;8(1):77- 81. (In Russ.). doi: 10.18499/2225-7357-2019-8-1-77-81
  • 12. Kraničić-Zec I, Dzamic A, Mitrovic S, Arsic-Arsenijevich V, Radonjic I. The role of parasites and fungi in secondary infertility. Med Pregl. 2004;57(1-2):30-32.
  • 13. Dzhangildinova SA, Edilbaeva TT, Turmukhambetova AA, Britko VV, Kinayatov MA, Rogova NR, i dr. The influence of ascarid invasion on morphological sperm-genesis indicators in men of reproductive age. Fundamental’nye Issledovaniya. 2013;(12 ч 2):205-208. (In Russ.).
  • 14. Lazareva OI. Cytopathic effects of the third-age somatic extract Anisakissimplex on eukaryotic and prokaryotic cells: monografiya. Perm, RF: IPTs Prokrost’; 2021. 171 р. (In Russ.).
  • 15. Hoseiny Asl Nazarlu Z, Matini M, Bahmanzadeh M, ForoughiParvar F. Toxoplasma gondii: a possible inducer of oxidative 27 stress in reproductive system of male rats. Iranian Journal of Parasitology. 2020 Oct-Dec;15(4):521-529. doi: 10.18502/ ijpa.v15i4.4857
  • 16. Cuesta DP, Martínez LM, Massaro MM, Agudelo CA, Hurtado IC, Miranda DC, et al. Evalution of the genotoxic effect of malaria in a cohort of patients in Medellin and Quidbo. Revista Chilena de Infectologí a. 2014 Oct;31(5):549-554. doi: 10.4067/S0716-10182014000500006
  • 17. Roh J, Lim YS, Seo MY, Choi Y, Ryu JS. The secretory products of Trichomonas vaginalis decrease fertilizing capacity of mice sperm in vitro. Asian Journal of Andrology. 2015 MarApr;17(2):319-323. doi: 10.4103/1008-682X.145070
  • 18. Keum J, Roh J, Ryu JS, Ryu KY. Excretory-secretory products of Trichomonas vaginalis cause apoptosis in mouse sperm in vitro. The Korean Journal of Parasitology. 2022 Oct;60(5):357- 360. doi: 10.3347/kjp.2022.60.5.357
  • 19. Pennington LF, Alouffi A, Mbanefo EC, Ray D, Heery DM, Jardetzky TS, et al. H-IPSE is a pathogen-secreted host nucleus-infiltrating protein (infiltrin) expressed exclusively by the schistosoma haematobium egg stage. Infection and Immunity. 2017 Nov;85(12):e00301-17. doi: 10.1128/ IAI.00301-17
  • 20. Sivkova TN. The karyopathic action of Toxocaracanis anitgenes in vivo. Vestnik Saratovskogo Gosudarstvennogo agrarnogo universiteta. 2010;(3):24-26. (In Russ.).
  • 21. Subbotina IA, Subbotin AM. Parasitic and infectious diseases as a pathway to cancer. V: Sovremennye problemy infektsionnoi patologii u zhivotnykh i lyudei: materialy Mezhdunar nauchprakt konf, posvyashch 90-letiyu kaf epizootologii i infekts boleznei zhivotnykh, Vitebsk, 23-24 okt 2017 g. Vitebsk, RB: VGAVM; 2017. Р. 74-78. (In Russ.).
  • 22. Sivkova TN. Karyopathic action of somatic products of Diphyllobothrium latum on red bone marrow cells. V: Donskoi gos agrar un-t. Sovremennye dostizheniya veterinarnoi meditsiny sel’skokhozyaistvennomu proizvodstvu: materialy Vseros nauch-prakt distants konf, pos Perisianovskii, 15-17 maya 2009 g. Persianovsky, RF: DonGAU; 2009. Р. 85-87. (In Russ.).
  • 23. Veloz A, Reyes-Vázquez L, Patricio-Gómez JM, Romano MC. Effect of mice Taenia crassiceps WFU cysticerci infection on the ovarian folliculogenesis, enzyme expression, and serum estradiol. Experimental Parasitology. 2019 Dec;207:107778. doi: 10.1016/j.exppara.2019.107778
  • 24. Arteaga-Silva M, Vargas-Villavicencio JA, ViguerasVillaseñor RM, Rodríguez-Dorantes M, Morales-Montor J. Taeniacrassiceps infection disrupts estrous cycle and reproductive behavior in BALB/c female mice. Acta Tropica. 2009 Feb;109(2):141-145. doi: 10.1016/j. actatropica.2008.10.011
  • 25. Mutovin GR, Ivanova OG, Zhilina SS. Reproductive genes and ontogenesis; major gender differentiations. Pediatriya Zhurnal im GN Speranskogo. 2009;88(6):40-47. (In Russ.).
  • 26. RUVIKI: tsifrovaya entsiklopediya. URL: https://ru.ruwiki.ru/ wiki [Accessed 05th August 2026]. (In Russ.).
  • 27. Synaptonemal complex. Vikipediya. URL: https:// ru.wikipedia.org [Accessed 05th August 2026]. (In Russ.).
  • 28. Bogdanov YuF, Grishaeva TM. Conservatism, Variability and the Evolution of Mitosis. Moscow, RF: Tovarishchestvo nauchnykh izdanii KMK; 2020. 345 р. (In Russ.).
  • 29. Grishaeva TM, Dadashev SYa, Bogdanov YuF. The meiotic ligaments of REC8 and their mitotic orthologs of RAD21: a comparison in silico. Molekulyarnaya Biologiya. 2007;41(4):743-745. (In Russ.).
  • 30. Bogdanov YuF. Protein mechanisms of meiosis. Priroda. 2008;(3):3-10. (In Russ.).
  • 31. Ishiguro KI, Matsuura K, Tani N, Takeda N, Usuki S, Yamane M, et al. MEIOSIN directs the switch from mitosis to meiosis in mammalian germ cells. Developmental Cell. 2020 Feb;52(4):429-445. doi: 10.1016/j.devcel.2020.01.010
  • 32. Markov A. Towards Unraveling the Mystery of Meiosis. Elementy: [sait]. URL: https://elementy.ru/genbio/ synopsis?artid=170 [Accessed 05th August 2026]. (In Russ.).
  • 33. Bogdanov YuF, Kolomiets OL. Synaptonemic complex - an indicator of meiosis dynamics and chromosome variability. Moscow, RF: Tovarishchestvo nauchnykh izdanii KMK; 2007. 328 р. (In Russ.).
  • 34. Shimada R, Kato Y, Takeda N, Fujimura S, Yasunaga KI, Usuki S, et al. STRA8-RB interaction is required for timely entry of meiosis in mouse female germ cells. Nature Communications. 2023 Oct;14(1):6443. doi: 10.1038/s41467-023-42259-6
  • 35. Kusz-Zamelczyk K, Sajek M, Spik A, Glazar R, Jędrzejczak P, Latos-Bieleńska A, et al. Mutation of NANOS1, a human homologue of the Drosophila morphogen, are associated with a lack of germ cells in testes or severe oligo-asthenoteratozoospermia. Journal of Medical Genetics. 2013 Mar;50(3):187-193. doi: 10.1136/jmedgenet-2012-101230
  • 36. Huang ZY, Zhang XS. Nanos2 in the male reproductive system: Progress in studies. Zhonghua nan ke xue = National journal of andrology. 2018 Jun;24(6):558-561.
  • 37. Vanessa T, Reijo Pera RA. NANOS3 function in human germ cell development. Human Molecular Genetics. 2011 Jun;20(11):2238-2250. doi: 10.1093/hmg/ddr114
  • 38. Oatley JM, Griswold MD. MEIOSIN: a new watchman of meiotic initiation in mammalian germ cells. Developmental Cell. 2020 Feb;52(4):397-398. doi: 10.1016/j. devcel.2020.02.002
  • 39. Ishiguro KI, Matsuura K, Tani N, Takeda N, Usuki S, Yamane M, et al. MEIOSIN directs the switch from mitosis to meiosis in mammalian germ cells. Developmental Cell. 2020 Feb;52(4):429-445.e10. doi: 10.1016/j.devcel.2020.01.010

Submitted 18.02.2026
Accepted 27.08.2026

Information about authors:

N.A. Kravchenko – senior lecturer of the Chair of Medical Biology and General Genetics, Vitebsk State Order of Peoples’ Friendship Medical University; Еkaterina S. Pashinskaya – Candidate of Biological Sciences, associate professor, Head of the Scientifi c and Educational Center “Center for Molecular Genetic and Biotechnological Research”, Vitebsk State Order of Peoples’ Friendship Medical University, htpps://orcid.org/0000-0002-5473-4240, e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра.;
V.V. Pobyarzhin – Candidate of Biological Sciences, associate professor of the Chair of Medical Biology and General Genetics, Dean of Overseas Students Training Faculty, Vitebsk State Order of Peoples’ Friendship Medical University, https://orcid.org/0000-0002-3508-9995;
А.М. Khnykau – Candidate of Medical Sciences, associate professor of the Chair of Infectious Diseases with the course of the Faculty for Advanced Training & Retraining, Vitebsk State Order of Peoples’ Friendship Medical University, https:// orcid.org/0009-0006-5832-2602.

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