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Sergiyevich A.V., Litvyakov A.M.
The comparative analysis of arginase I serumal level in patients with psoriasis and psoriatic arthritis

Abstract. Arginase is an enzyme, which causes hydrolysis of L-arginine with ornithine and urea formation. Arginase can inhibit nitrogen oxide (NO) synthesis, competing with NOS for L-arginine. Patients with psoriasis,  psoriatic arthritis and the control group - healthy people have been examined. In patients with psoriatic arthritis and psoriasis the serumal level of arginase is reliably higher than in the control group. The serumal level of arginase I in patients with psoriasis is reliably higher than in patients with psoriatic arthritis. When a change of clinical situation occurs arginase I serumal level most strongly and statistically significantly correlates with quickly altering indicators reflecting an inflammatory process, accompanied by the destruction of the cells containing arginase I. Endothelium dysfunction and atherosclerosis provide long stable level of arginase I in blood serum. For patients with psoriatic arthritis both dermal, and articular processes are the independent factors considerably enlarging the level of arginase I. For patients with psoriasis an integument lesion is a major factor determining significant rise in the level of arginase I.
Key words: psoriasis, psoriatic arthritis, arginase I.

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