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Sergiyevich A.V., Litvyakov A.M.
The comparative analysis of TNF-a, IL-1b, IL-6 serumal level in patients with psoriasis and  psoriatic arthritis

Abstract. In patients with psoriasis the enlarged production ­ and secretion of cytokines and growth factors activated by T-lymphocytes cause the basic proliferation of skin cells, pathological limiting differentiation and fastness to apoptotic signals. Patients with psoriasis, psoriatic arthritis and the control group - healthy people have been examined.  Statistically significant positive correlation of TNF-a, IL-1b, IL-6 between themselves has been revealed in the investigated groups of patients. The serumal levels of TNF-a, IL-1b, IL-6 in the surveyed groups were higher, than in the control group, moreover, they were reliably higher in the group of patients with psoriatic arthritis. In psoriasis both with joints lesion, and without it the proportional essential augmentation of proinflammatory cytokines (TNF-a, IL-1b, IL-6) occurs. In the presence of an articular syndrome this rise in the  serumal level of cytokines is more expressed, than in case when only the integument is damaged by psoriatic process.
Key words: TNF-K, IL-1b, IL-6, psoriasis, psoriatic arthritis.

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