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Podpalov V.P., Balashenko N.S.
Remodelling of the cardiovascular system in patients with arterial hypertension of the 1st and the 2nd degree
Education establishment "Vitebsk State Order of Peoples’ Friendship Medical University", Belarus

Abstract.
Objective. To study the cardiovascular system remodelling in patients with arterial hypertension of the 1st and the 2nd degree.
Material and methods. 265 patients with arterial hypertension of the 1st and the 2nd degree as well as persons constituting the control group were examined. The  data of the standard questionnaire, office BP measurement, ambulatory blood pressure monitoring, electrocardiography (ECG), Holter ECG monitoring, echocardiography, brachiocephalic arteries ultrasound investigation, pulse wave velocity determination, biochemical serum and urine  analyses results (lipid parameters, C-reactive protein, glucose, creatinine and microalbumin) were evaluated.
Results. Remodelling processes in patients with arterial hypertension of the 1st and the 2nd degree were revealed according to the ECG data, the results of echocardiography. Arteries remodelling processes in patients with arterial hypertension of the 1st and the 2nd degree were ascertained in comparison with practically healthy surveyed persons on the basis of the evaluation of pulse wave velocity by rheography method, changes in the structure of the arterial wall by ultrasound. It has also been found that in patients with arterial hypertension of the 1st and the 2nd degree changes in biochemical parameters of blood serum are observed in the form of higher values of TC, triglycerides, LDL-C, C-reactive protein and lower levels of HDL-C compared with those of the control group.
Key words: arterial hypertension, remodelling, cardiovascular system.

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