Sergiyevich A.V.
Clinical and laboratory peculiarities of patients with psoriasis
Education Establishment "Vitebsk State Order of Peoples’ Friendship Medical University", Republic of Belarus
Abstract.
Psoriasis is widespread, hereditary, T-cellular, chronic dermatosis with the benign hyperproliferation of epitheliocytes, the disturbance of their differentiation and keratinization as well as with organs and systems pathology. 56 persons with psoriasis without joints lesion were included in this research. The control group consisted of 26 healthy people. In persons with psoriasis without joints lesion the serumal level of arginase I was statistically significantly higher, than that in the control group; statistically significant moderate positive correlation between TNF-e, IL-1, and IL-6 was found; proatherogenic changes of lipide profile indices (increase of serumal levels of TC, LDL-C, TG, VLDL-C and decrease of serumal level of HDL-C) were determined. For the group with psoriasis moderate positive correlation of arginase I with PASI index and age; TC, TG, VLDL-C with the patients’ age was revealed.
Key words: psoriasis, arginase I, interleukins, lipids.
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